1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-
- Product Name
- 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-
- CAS No.
- 1034667-22-5
- Chemical Name
- 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-
- Synonyms
- 3-Amino-5-fluoro-1H-pyraz...;3-Amino-5-fluoropyrazolo[3,4-b]pyridine;5-FLUORO-2H-PYRAZOLO[3,4-B]PYRIDIN-3-AMINE;5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine;3-AMino-5-fluoro-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro-;5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-ylaMine
- CBNumber
- CB42525266
- Molecular Formula
- C6H5FN4
- Formula Weight
- 152.13
- MOL File
- 1034667-22-5.mol
1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Property
- Boiling point:
- 408.7±40.0 °C(Predicted)
- Density
- 1.604±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.71±0.40(Predicted)
- Appearance
- Light yellow to green yellow Solid
- InChI
- InChI=1S/C6H5FN4/c7-3-1-4-5(8)10-11-6(4)9-2-3/h1-2H,(H3,8,9,10,11)
- InChIKey
- UFONWAPOQPJJLL-UHFFFAOYSA-N
- SMILES
- C12NN=C(N)C1=CC(F)=CN=2
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PC53221
- Product name
- 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-0037437
- Product name
- 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 0832AA
- Product name
- 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
- Packaging
- 250mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- PC53221
- Product name
- 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
- Packaging
- 1g
- Price
- $199
- Updated
- 2021/12/16
- Product number
- CS-0037437
- Product name
- 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine
- Packaging
- 100mg
- Price
- $95
- Updated
- 2021/12/16
1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Chemical Properties,Usage,Production
Synthesis
791644-48-9
1034667-22-5
The general procedure for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine from 2-chloro-5-fluoro nicotinonitrile was as follows: to a solution of 2-chloro-5-fluoro nicotinonitrile (50 g, 321.7 mmol) in 1-butanol (1 L) was added hydrazine monohydrate (150 mL, 3.2 mol) and the mixture was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated. The resulting precipitate was washed sequentially with water (twice) and ether (twice) and subsequently dried under vacuum overnight to afford 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine (44 g, 88% yield) as a yellow solid.1H NMR (DMSO-d6, 300 MHz) data were as follows: δ 5.53 (s, 2H); 7.94 (dd, 1H); 8.35 (dd, 1H); 12.02 (s, 1H).
References
[1] Patent: WO2008/77086, 2008, A1. Location in patent: Page/Page column 56; 58
[2] Patent: WO2009/18415, 2009, A1. Location in patent: Page/Page column 35-37
[3] Patent: US2011/20377, 2011, A1. Location in patent: Page/Page column 12; 13
[4] Patent: WO2008/112642, 2008, A1. Location in patent: Page/Page column 51-52
[5] Patent: WO2008/112646, 2008, A1. Location in patent: Page/Page column 51
1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- manufacturers
- Product
- 1H-Pyrazolo[3,4-b]pyridin-3-amine, 5-fluoro- 1034667-22-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-12
- Product
- 5-Fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine 1034667-22-5
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 10 tons
- Release date
- 2023-03-02
- Product
- 3-AMino-5-fluoro-1H-pyrazolo[3,4-b]pyridine 1034667-22-5
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02