4-chloro-6-methoxyquinolin-7-ol
- Product Name
- 4-chloro-6-methoxyquinolin-7-ol
- CAS No.
- 205448-31-3
- Chemical Name
- 4-chloro-6-methoxyquinolin-7-ol
- Synonyms
- Bedaquiline Impurity 133;4-chloro-6-methoxyquinolin-8-ol;4-Chloro-6-Methoxy-7-quinolinol;4-chloro-6-methoxyquinolin-7-ol;7-Quinolinol, 4-chloro-6-methoxy-;4-Chloro-7-hydroxy-6-Methoxyquinolin;4-chloro-6-methoxy-1H-quinolin-7-one;4-Chloro-6-methoxy-7-hydroxyquinoline;4-Chloro-7-hydroxy-6-methoxyquinoline
- CBNumber
- CB42526056
- Molecular Formula
- C10H8ClNO2
- Formula Weight
- 209.63
- MOL File
- 205448-31-3.mol
4-chloro-6-methoxyquinolin-7-ol Property
- Boiling point:
- 353℃
- Density
- 1.386
- Flash point:
- 168℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.41±0.40(Predicted)
- form
- solid
- color
- White to light brown
- InChI
- InChI=1S/C10H8ClNO2/c1-14-10-4-6-7(11)2-3-12-8(6)5-9(10)13/h2-5,13H,1H3
- InChIKey
- NKWZPFHSWLSOON-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(OC)=C(O)C=2)C(Cl)=CC=1
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C596690
- Product name
- 4-Chloro-6-methoxyquinolin-7-ol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC30699
- Product name
- 4-Chloro-6-methoxyquinolin-7-ol
- Packaging
- 5G
- Price
- $262.5
- Updated
- 2021/12/16
- Product number
- X0263
- Product name
- 4-Chloro-6-methoxyquinolin-7-ol
- Packaging
- 250mg
- Price
- $33
- Updated
- 2021/12/16
- Product number
- J97452
- Product name
- 4-Chloro-6-methoxyquinolin-7-ol
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- OR903690
- Product name
- 4-Chloro-6-methoxyquinolin-7-ol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
4-chloro-6-methoxyquinolin-7-ol Chemical Properties,Usage,Production
Chemical Properties
Brown solid
Synthesis
286371-49-1
205448-31-3
General procedure for the synthesis of 7-hydroxy-4-chloro-6-methoxyquinoline from 7-(benzyloxy)-4-chloro-6-methoxyquinoline: the compound 7-(benzyloxy)-4-chloro-6-methoxyquinoline (16 g, 53.37 mmol) was dissolved in trifluoroacetic acid (100 mL), and methanesulfonic acid (6.1 mL, 93.94 mmol) was added in one go. The reaction mixture was stirred under reflux conditions for 3 hours and subsequently cooled to room temperature. The solvent was removed by evaporation and the pH of the residue was adjusted to 7 with 2.5 N sodium hydroxide solution.The resulting solid was crushed into small pieces and the mixture was stirred vigorously for 2 hr. The solid was collected by filtration and dried under high vacuum to give 7-hydroxy-4-chloro-6-methoxyquinoline (11.3 g, yield = 100%) as a light brown solid.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 18, p. 5766 - 5779
[2] Patent: US2014/235634, 2014, A1. Location in patent: Paragraph 0356; 0362
[3] Patent: CN106749231, 2017, A. Location in patent: Paragraph 0080; 0081; 0092; 0093
4-chloro-6-methoxyquinolin-7-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-chloro-6-methoxyquinolin-7-ol manufacturers
- Product
- 4-chloro-6-methoxyquinolin-7-ol 205448-31-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 4-chloro-6-methoxyquinolin-7-ol 205448-31-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 4-chloro-6-methoxyquinolin-7-ol 205448-31-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07