(S)-TERT-LEUCINOL
- Product Name
- (S)-TERT-LEUCINOL
- CAS No.
- 112245-13-3
- Chemical Name
- (S)-TERT-LEUCINOL
- Synonyms
- L-TERT-LEUCINOL;H-TLE-OL;L-T-LEUCINOL;H-(TBU)GLY-OL;(S)-TERT-LEACINOL;(S)-TERT-LEUCINOL;L-T-BUTYLGLYCINOL;(S)-TERT-LENCINOL;(+)-tert-Leucinol;L**L-tert-Leucinol
- CBNumber
- CB4253158
- Molecular Formula
- C6H15NO
- Formula Weight
- 117.19
- MOL File
- 112245-13-3.mol
(S)-TERT-LEUCINOL Property
- Melting point:
- 30-34 °C(lit.)
- Boiling point:
- 114-116 °C (10 mmHg)
- Density
- 0.9 g/mL at 25 °C(lit.)
- refractive index
- 38 ° (C=1.5, EtOH)
- Flash point:
- 194 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Methanol
- pka
- 12.88±0.10(Predicted)
- form
- Crystalline Low Melting Mass or Liquid
- color
- White or colorless
- optical activity
- [α]26/D +37°, c = 1.5 in ethanol
- BRN
- 3600321
- Major Application
- peptide synthesis
- InChI
- InChI=1S/C6H15NO/c1-6(2,3)5(7)4-8/h5,8H,4,7H2,1-3H3/t5-/m1/s1
- InChIKey
- JBULSURVMXPBNA-RXMQYKEDSA-N
- SMILES
- C(O)[C@@H](N)C(C)(C)C
- CAS DataBase Reference
- 112245-13-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 407739
- Product name
- L-tert-Leucinol
- Purity
- 98%
- Packaging
- 1g
- Price
- $41.3
- Updated
- 2025/07/31
- Product number
- 407739
- Product name
- L-tert-Leucinol
- Purity
- 98%
- Packaging
- 5g
- Price
- $100.93
- Updated
- 2025/07/31
- Product number
- L0160
- Product name
- L-tert-Leucinol
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $62
- Updated
- 2025/07/31
- Product number
- L0160
- Product name
- L-tert-Leucinol
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $186
- Updated
- 2025/07/31
- Product number
- 07-7224
- Product name
- L-tert-Leucinol, 98% (99% ee)
- Packaging
- 1g
- Price
- $67
- Updated
- 2024/03/01
(S)-TERT-LEUCINOL Chemical Properties,Usage,Production
Chemical Properties
white crystalline low melting mass or
Uses
Useful amino acid employed in various asymmetric reactions.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
20859-02-3
112245-13-3
GENERAL STEPS: Example 8-1; To a 100 mL Schlenk tube purged with nitrogen was added 4.00 g (30.5 mmol) of (S)-tert-leucine and 40 mL of tetrahydrofuran, and the temperature of the reaction system was adjusted to 10°C. Over 5 min, 1.46 g (61.0 mmol) of lithium borohydride was added to the suspension in batches, followed by adjusting the temperature of the system to 20 °C. Over 30 minutes, 7.44 g (67.1 mmol) of trimethylmethylsilyl chloride was added slowly and dropwise, then the mixture was heated to 65 °C and stirred continuously at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to 10 °C and quenched by the slow dropwise addition of 4 mL of methanol over 20 min. After concentrating the reaction mixture using a rotary evaporator, 40 mL of 4 M aqueous sodium hydroxide solution was added and stirred for 1 hour at room temperature. Subsequently, 40 mL of tert-butyl methyl ether was added for extraction and the organic layer was separated and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the tert-butyl methyl ether was removed by atmospheric pressure distillation. Finally, the 70 to 75 °C fraction was collected by reduced pressure distillation (0.3 kPa) to give 2.96 g of (S)-tert-leucinol in 83% yield.
References
[1] Journal of the American Chemical Society, 2003, vol. 125, # 21, p. 6362 - 6363
[2] Chemical Communications, 2010, vol. 46, # 3, p. 445 - 447
[3] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1637 - 1642
[4] Journal of Organic Chemistry, 1992, vol. 57, # 17, p. 4732 - 4740
[5] Organic Letters, 2018, vol. 20, # 16, p. 4806 - 4810
(S)-TERT-LEUCINOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-TERT-LEUCINOL manufacturers
- Product
- (S)-TERT-LEUCINOL 112245-13-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-07-06
- Product
- (S)-tert-Leucinol 112245-13-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-25