TQS

Product Name: TQS
CAS No.: 353483-92-8
Chemical Name: TQS
Synonyms: TQS;TQS, 10 mM in DMSO;4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide;3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide;3H-Cyclopenta[c]quinoline-8-sulfonamide, 3a,4,5,9b-tetrahydro-4-(1-naphthalenyl)-;Inhibitor,modulator,acetylcholine,Nicotinic acetylcholine receptors,nAChR,allosteric,neuroinflammatory,positive,pain,inhibit,TQS,nicotinic
CBNumber: CB42535704
Molecular Formula: C22H20N2O2S
Formula Weight: 376.47
MOL File: 353483-92-8.mol

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TQS Property

Boiling point:: 609.8±65.0 °C(Predicted)
Density: 1.311±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble to 50 mM in DMSO
form: Powder
pka: 10.21±0.40(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3316
Product name: TQS
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $89.39
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3316
Product name: TQS
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $378
Updated: 2025/07/31

Tocris

Product number: 4233
Product name: TQS
Purity: ≥98%(HPLC)
Packaging: 10
Price: $152
Updated: 2021/12/16

Tocris

Product number: 4233
Product name: TQS
Purity: ≥98%(HPLC)
Packaging: 50
Price: $675
Updated: 2021/12/16

Usbiological

Product number: 256951
Product name: TQS
Packaging: 10mg
Price: $446
Updated: 2021/12/16

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TQS Chemical Properties,Usage,Production

Uses

TQS is a positive allosteric modulator (Type II) of alpha7 nACh receptors, functional human α7 nicotinic acetylcholine receptor (nAChR) generated from Escherichia coli that opens a new avenue for producing mammalian Cys-loop receptors to facilitate structure-based rational drug design.

Biological Activity

TQS is a type-II positive allosteric modulator of α7 nAChR. TQS potentiates agonist-invoked responses, and dramatically reduces the rate of desensitization of α7 nAChR. The compound has no agonist activity alone. The EC50 for potentiation of submaximal doses of acetylcholine is 6.2μM.

in vivo

TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus^[1].

Animal Model:	Male C57BL/6J mice^[1]
Dosage:	1 or 4 mg/kg
Administration:	I.p.
Result:	Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus.

TQS Preparation Products And Raw materials

Raw materials

Preparation Products

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TQS Suppliers

China 32 United Kingdom 1 United States 5 USA 1 Global 39

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Kaifeng Mingren Pharmaceutical Co.,LTD

Tel: 0371-65741762
Fax: QQ：2860768577
Email: sales@hasunny.com
Country: China
ProdList: 2380
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

353483-92-8, TQSRelated Search:

TQS

3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide

4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide

Inhibitor,modulator,acetylcholine,Nicotinic acetylcholine receptors,nAChR,allosteric,neuroinflammatory,positive,pain,inhibit,TQS,nicotinic

3H-Cyclopenta[c]quinoline-8-sulfonamide, 3a,4,5,9b-tetrahydro-4-(1-naphthalenyl)-

TQS, 10 mM in DMSO

353483-92-8