2-Cyclopropylaminonicotinic acid

Product Name: 2-Cyclopropylaminonicotinic acid
CAS No.: 639807-18-4
Chemical Name: 2-Cyclopropylaminonicotinic acid
Synonyms: 3-Pyridinecarboxylic acid, 2-(cyclopropylamino)-
CBNumber: CB42535719
Molecular Formula: C9H10N2O2
Formula Weight: 178.19
MOL File: 639807-18-4.mol

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2-Cyclopropylaminonicotinic acid Property

Boiling point:: 380.1±27.0 °C(Predicted)
Density: 1.437
storage temp.: Sealed in dry,Room Temperature
pka: 1.82±0.36(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C999025
Product name: 2-(Cyclopropylamino)nicotinicacid
Packaging: 100mg
Price: $175
Updated: 2021/12/16

AK Scientific

Product number: 5058CR
Product name: 2-(Cyclopropylamino)nicotinicacid
Packaging: 10g
Price: $232
Updated: 2021/12/16

Apolloscientific

Product number: OR958277
Product name: 2-Cyclopropylaminonicotinicacid
Purity: 95%
Packaging: 5g
Price: $335
Updated: 2021/12/16

AK Scientific

Product number: 5058CR
Product name: 2-(Cyclopropylamino)nicotinicacid
Packaging: 250mg
Price: $74
Updated: 2021/12/16

Apolloscientific

Product number: OR958277
Product name: 2-Cyclopropylaminonicotinicacid
Purity: 95%
Packaging: 1g
Price: $125
Updated: 2021/12/16

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2-Cyclopropylaminonicotinic acid Chemical Properties,Usage,Production

Synthesis

52583-90-1

639807-18-4

1. Potassium hydroxide (KOH) pellets are added to a reaction system containing a water (H2O)/isopropanol (IPA) mixture of 2-(cyclopropylamino)nicotinonitrile under vigorous stirring (45% potassium hydroxide solution may also be used instead). An exothermic phenomenon from room temperature to 40 °C was observed during the reaction. 2. The temperature of the reaction system was raised to 80°C and maintained under reflux conditions for about 12 hours. The progress of the reaction was monitored by high performance liquid chromatography (HPLC) and after complete consumption of the feedstock, the mixture was cooled down to 0-5 °C and the pH was adjusted to about 6 by slow dropwise addition of 37% hydrochloric acid (HCl) while controlling the temperature below 10 °C. 3. The product, 2-cyclopropylidene, was added to the reaction system at room temperature. 3. The product 2-cyclopropylaminonicotinic acid (2-CAN) precipitated as a white solid and was separated by vacuum filtration. The wet cake was washed with minimal water and dried under vacuum at 70-80 °C to a constant weight. The final product 2-CAN was 23.40 g in 91% yield.

References

[1] Patent: WO2016/118586, 2016, A1. Location in patent: Page/Page column 30
[2] Patent: US2004/2603, 2004, A1. Location in patent: Page 3
[3] Green Chemistry, 2017, vol. 19, # 13, p. 2986 - 2991

2-Cyclopropylaminonicotinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Cyclopropylaminonicotinic acid Suppliers

China 32 Germany 1 India 1 Italy 1 United States 3 Global 38

Zhejiang Qiming Pharmaceutical Co., Ltd.

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CONIER CHEM AND PHARMA LIMITED

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View Lastest Price from 2-Cyclopropylaminonicotinic acid manufacturers

Hebei Xinsheng New Material Technology Co., LTD.

Product: 2-Cyclopropylaminonicotinic acid 639807-18-4
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 Ton
Release date: 2023-11-16

639807-18-4, 2-Cyclopropylaminonicotinic acidRelated Search:

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3-Pyridinecarboxylic acid, 2-(cyclopropylamino)-

639807-18-4