Vicriviroc Malate
- Product Name
- Vicriviroc Malate
- CAS No.
- 541503-81-5
- Chemical Name
- Vicriviroc Malate
- Synonyms
- CS-599;Vicriviroc Malate;1-[(4,6-Dimethyl-5-pyrimidinyl)carbonyl]-4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methyl-1-piperazinyl]-4-methylpiperidine malate
- CBNumber
- CB42537571
- Molecular Formula
- C32H44F3N5O7
- Formula Weight
- 667.7162696
- MOL File
- 541503-81-5.mol
Vicriviroc Malate Property
- storage temp.
- Store at -20°C
- solubility
- >18mg/mL in DMSO
- form
- Powder
- InChIKey
- HQJIGHNTROUVLT-RIAYWLAYSA-N
N-Bromosuccinimide Price
- Product number
- A2589
- Product name
- (4,6-dimethylpyrimidin-5-yl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone;2-hydroxybutanedioic acid
- Packaging
- 5mg
- Price
- $307
- Updated
- 2021/12/16
- Product number
- X5032
- Product name
- Vicrivirocmalate
- Packaging
- 5mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- 42612
- Product name
- VicrivirocMalate
- Packaging
- 2.5mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- INB0000878
- Product name
- VICRIVIROC MALATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $825.83
- Updated
- 2021/12/16
- Product number
- 42612
- Product name
- VicrivirocMalate
- Packaging
- 50mg
- Price
- $1325
- Updated
- 2021/12/16
Vicriviroc Malate Chemical Properties,Usage,Production
Uses
Vicriviroc (SCH 417690) malate is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc malate can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer[1][2].
Definition
ChEBI: (4,6-Dimethylpyrimidin-5-yl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone;2-hydroxybutanedioic acid is a member of (trifluoromethyl)benzenes.
target
CCR5
References
[1] Strizki JM, et al. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob Agents Chemother. 2005;49(12):4911-4919. DOI:10.1128/AAC.49.12.4911-4919.2005
[2] Bessudo A, et al. Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab in Patients With Advanced or Metastatic Microsatellite Stable Colorectal Cancer. Clin Colorectal Cancer. 2024;23(3):285-294. DOI:10.1016/j.clcc.2024.05.003
Vicriviroc Malate Preparation Products And Raw materials
Raw materials
Preparation Products
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