KD 5170
- Product Name
- KD 5170
- CAS No.
- 940943-37-3
- Chemical Name
- KD 5170
- Synonyms
- KD 5170;KD5170; KD-5170;S-(2-(6-(4-(3-(DiMethylaMino)propoxy)phenylsulfonaMido)pyridin-3-yl)-2-oxoethyl) ethanethioate;S-(2-{6-[({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)amino]-3-p Yridinyl}-2-oxoethyl) Ethanethioate;Ethanethioic acid, S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester
- CBNumber
- CB42538280
- Molecular Formula
- C20H25N3O5S2
- Formula Weight
- 451.56
- MOL File
- 940943-37-3.mol
KD 5170 Property
- Boiling point:
- 637.9±65.0 °C(Predicted)
- Density
- 1.310±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- ≥21.2 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
- form
- solid
- pka
- 9.29±0.28(Predicted)
N-Bromosuccinimide Price
- Product number
- 13214
- Product name
- KD 5170
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 13214
- Product name
- KD 5170
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- 13214
- Product name
- KD 5170
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- 13214
- Product name
- KD 5170
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $465
- Updated
- 2024/03/01
- Product number
- 255590
- Product name
- KD 5170
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
KD 5170 Chemical Properties,Usage,Production
Description
KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively). It exhibits broad spectrum antitumor activity in vitro and in vivo. KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.
References
[1]. hassig ca, symons kt, guo x, et al. kd5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo. mol cancer ther, 2008, 7(5): 1054-1065.
[2]. payne je, bonnefous c, hassig ca, et al. identification of kd5170: a novel mercaptoketone-based histone deacetylase inhibitor. bioorg med chem lett, 2008, 18(23): 6093-6096.
[3]. feng r, ma h, hassig ca, et al. kd5170, a novel mercaptoketone-based histone deacetylase inhibitor, exerts antimyeloma effects by dna damage and mitochondrial signaling. mol cancer ther, 2008, 7(6): 1494-1505.
KD 5170 Preparation Products And Raw materials
Raw materials
Preparation Products
KD 5170 Suppliers
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View Lastest Price from KD 5170 manufacturers
- Product
- KD 5170 940943-37-3
- Price
- US $1.80/KG
- Min. Order
- 1g
- Purity
- 96%-99%
- Supply Ability
- 1kg/10kg/100kg
- Release date
- 2020-11-11