tert-butyl 3-acetylazetidine-1-carboxylate
- Product Name
- tert-butyl 3-acetylazetidine-1-carboxylate
- CAS No.
- 870089-49-9
- Chemical Name
- tert-butyl 3-acetylazetidine-1-carboxylate
- Synonyms
- 1-Boc-3-acetyl-azetidine;1-Boc-3-acetylazetidine - [A10808];2-methylthiazole-16-carboxylic acid;Oxirane, 2-[6-(phenylMethoxy)ethyl]-;TERT-BUTYL 3-ACETYLAZETIDINE-1-CARBOXYLATE;1-Azetidinecarboxylic acid, 3-acetyl-, 1,1-dimethylethyl ester;3-neneneba acetyl azacyclobutane-1-carboxylic acid tert butyl ester
- CBNumber
- CB42550583
- Molecular Formula
- C10H17NO3
- Formula Weight
- 199.25
- MOL File
- 870089-49-9.mol
tert-butyl 3-acetylazetidine-1-carboxylate Property
- Boiling point:
- 274.7±33.0 °C(Predicted)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -2.86±0.40(Predicted)
- Appearance
- Colorless to off-white Solid-Liquid Mixture
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB159193
- Product name
- 1-Boc-3-acetylazetidine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 9762BB
- Product name
- Tert-butyl3-acetylazetidine-1-carboxylate
- Packaging
- 250mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- FB159193
- Product name
- 1-Boc-3-acetylazetidine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB159193
- Product name
- 1-Boc-3-acetylazetidine
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB159193
- Product name
- 1-Boc-3-acetylazetidine
- Packaging
- 2g
- Price
- $320
- Updated
- 2021/12/16
tert-butyl 3-acetylazetidine-1-carboxylate Chemical Properties,Usage,Production
Synthesis
820971-67-3
75-16-1
870089-49-9
B. Preparation of tert-butyl 3-acetylazetidine-1-carboxylate (C56). A solution of tert-butyl 3-[methoxy(methyl)carbamoyl]azetidine-1-carboxylate (C55) (27.1 g, 0.111 mol) in tetrahydrofuran (THF) (200 mL) was slowly added dropwise to a mixture of 1.4 M methylmagnesium bromide in a mixture of tetrahydrofuran and toluene (25:75) (99.0 mL, 0.139 mol) for a controlled dropwise time of 40 min while maintaining the reaction temperature at about 0 °C. After the dropwise addition, the reaction mixture was stirred at 10-15°C for 2 hours, followed by continued stirring at room temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with 10% aqueous citric acid (150 mL). The organic phase was separated and the aqueous phase was extracted with ethyl acetate (EtOAc) (2 x 300 mL). The organic phases were combined, washed with saturated aqueous sodium chloride (2×250 mL) and dried over anhydrous sodium sulfate. After filtration, the solvent was removed by concentration under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: chloroform) to afford the target compound C56. yield: 20.6 g, 0.10 mol, 93% yield.1H NMR (400 MHz, CDCl3): δ 4.04-4.02 (m, 4H), 3.43-3.35 (m, 1H), 2.16 (s, 3H), 1.42 (s, 9H) .
References
[1] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 31-32
[2] Patent: WO2010/131145, 2010, A1. Location in patent: Page/Page column 87
[3] Patent: US2015/361067, 2015, A1. Location in patent: Paragraph 0621
[4] Patent: WO2018/137573, 2018, A1. Location in patent: Page/Page column 65; 66
[5] Patent: WO2014/173289, 2014, A1. Location in patent: Paragraph 0296; 0300; 0301
tert-butyl 3-acetylazetidine-1-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from tert-butyl 3-acetylazetidine-1-carboxylate manufacturers
- Product
- tert-butyl 3-acetylazetidine-1-carboxylate 870089-49-9
- Price
- US $2.00-6.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-ton
- Release date
- 2025-07-28
- Product
- tert-butyl 3-acetylazetidine-1-carboxylate 870089-49-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31