tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

Product Name: tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
CAS No.: 1147557-97-8
Chemical Name: tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms: 2-Boc-6-hydroxy-2-aza-spi...;2-Boc-6-hydroxy-2-aza-spiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;6-Hydroxy-2-azaspiro[3.3]heptane, N-BOC protected;tert-Butyl 2-hydroxy-6-azaspiro[3.3]heptane-6-carboxylate;tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate;1,1-Dimethylethyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate;6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester;tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate ISO 9001：2015 REACH;2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-hydroxy-, 1,1-diMethylethyl ester
CBNumber: CB32470891
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 1147557-97-8.mol

More

Less

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Property

Melting point:: 127-129℃
Boiling point:: 316.6±42.0 °C(Predicted)
Density: 1.17
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 14.84±0.20(Predicted)
form: Solid
color: White to Off-White
InChI: InChI=1S/C11H19NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h8,13H,4-7H2,1-3H3
InChIKey: UMXXHZDEAZUQKZ-UHFFFAOYSA-N
SMILES: C1C2(CC(O)C2)CN1C(OC(C)(C)C)=O

More

Less

Safety

HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D6214
Product name: tert-Butyl 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Purity: min. 98.0 %
Packaging: 1G
Price: $75
Updated: 2025/07/31

TRC

Product number: B809463
Product name: tert-Butyl6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Packaging: 250mg
Price: $95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-8J
Product name: tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate
Purity: 95%
Packaging: 1g
Price: $96
Updated: 2021/12/16

Synthonix

Product number: H6094
Product name: 6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylicacidtert-butylester
Purity: 97.0%
Packaging: 5g
Price: $150
Updated: 2021/12/16

Apolloscientific

Product number: OR301181
Product name: 6-Hydroxy-2-azaspiro[3.3]heptane,N-BOCprotected
Packaging: 1g
Price: $87
Updated: 2021/12/16

More

Less

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties,Usage,Production

Uses

tert-?Butyl 6-?Hydroxy-?2-?azaspiro[3.3]?heptane-?2-?carboxylate is a reactant used in the synthesis of pharmaceuticals such as CNS penetrant CXCR2 antagonists for the potential treatment of CNS demyelinating.

Synthesis

1181816-12-5

1147557-97-8

Step 8: Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate At 0 °C and under nitrogen protection, tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate (507 mg, 2.4 mmol) was dissolved in methanol (5.0 mL) and sodium borohydride (182 mg, 4.8 mmol) was added slowly. The reaction mixture was stirred at 0 °C for 30 min. After completion of the reaction, the solvent was concentrated in vacuum by rotary evaporator to give the crude product. Saturated sodium bicarbonate solution (30 mL) was added to the crude product and the aqueous phase was extracted with dichloromethane (4 x 30 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to afford tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (5 mg, 100% yield) as a white solid.1H NMR (300 MHz, CDCl3): δ 4.18 (m, 1H), 3.88 (d, 4H), 2.53 (m, 2H), 2.08 (m. 2H), 1.42 (s, 9H).

References

[1] Patent: WO2013/13308, 2013, A1. Location in patent: Paragraph 00178-00180
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5663 - 5672
[3] Patent: CN106565706, 2017, A. Location in patent: Paragraph 0179; 0180; 0181
[4] Patent: EP3281942, 2018, A1. Location in patent: Paragraph 0105; 0106
[5] Patent: WO2018/133858, 2018, A1. Location in patent: Paragraph 00221

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate Suppliers

China 131 India 1 United Kingdom 1 United States 11 Global 144

Yutong Pharmaceutical Technology (Suzhou) Co., Ltd.

Tel: 0512-15851462628 15851462628
Email: 2680463261@qq.com
Country: China
ProdList: 4996
Advantage: 58

BTC Pharmaceutical CO. Ltd

Tel: 15716293042 18862996710
Fax: 0513-68015394
Email: 15050603958@163.com
Country: China
ProdList: 694
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Nanjing Habo Medical Technology Co., Ltd.

Tel: 025-85760892 13376080562
Fax: 025-85766769
Email: sales@habotech.com
Country: China
ProdList: 884
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Chem-Milestone Co., Ltd

Tel: 021-50273253 13641951838
Fax: +86-21-61294436
Email: chemmilestone@163.com
Country: China
ProdList: 151
Advantage: 62

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: sales@uhnshanghai.com
Country: China
ProdList: 998
Advantage: 58

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

More

Less

View Lastest Price from tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate 1147557-97-8
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-08-06

Career Henan Chemical Co

Product: tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate 1147557-97-8
Price: US $1.00/KG
Min. Order: 100g
Purity: 98%
Supply Ability: 200KG
Release date: 2019-12-17

1147557-97-8, tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylateRelated Search:

Trolox 6-Hydroxypicolinic acid 8-AZAGUANINE 7-Azaindole exo-6-Hydroxy-2-aza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 3-(Boc-aMinoMethyl)-3-hydroxypyrrolidine tert-butyl 3-acetylazetidine-1-carboxylate (3S,5R)-3-(Boc-aMino)-5-Methylpiperidine (4aS,7aS)-tert-butyl octahydropyrrolo[3,4-b]pyridine-1-carboxylate cis-3-(Boc-aMino)-5-(trifluorMethyl)piperidine

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

2-Boc-6-hydroxy-2-aza-spi...

2-Boc-6-hydroxy-2-aza-spiro[3.3]heptane

6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester

2-Azaspiro[3.3]heptane-2-carboxylic acid, 6-hydroxy-, 1,1-diMethylethyl ester

6-Hydroxy-2-azaspiro[3.3]heptane, N-BOC protected

tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate, 2-(tert-Butoxycarbonyl)-6-hydroxy-2-azaspiro[3.3]heptane

tert-Butyl 2-hydroxy-6-azaspiro[3.3]heptane-6-carboxylate

tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate ISO 9001：2015 REACH

1,1-Dimethylethyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

6-Hydroxy-2-azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester - [H6094]

1147557-97-8