ChemicalBook > CAS DataBase List > WYE 354-d3
WYE 354-d3
- Product Name
- WYE 354-d3
- CAS No.
- 1794791-66-4
- Chemical Name
- WYE 354-d3
- Synonyms
- WYE 354-d3;4-[6-[4-[[(Methoxy-d3)carbonyl]aMino]phenyl]-4-(4-Morpholinyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester
- CBNumber
- CB42551409
- Molecular Formula
- C24H29N7O5
- Formula Weight
- 495.54
- MOL File
- 1794791-66-4.mol
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N-Bromosuccinimide Price
TRC
- Product number
- W950002
- Product name
- WYE354-d3
- Packaging
- 10mg
- Price
- $1760
- Updated
- 2021/12/16
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WYE 354-d3 Chemical Properties,Usage,Production
Uses
A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.
WYE 354-d3 Preparation Products And Raw materials
Raw materials
Preparation Products
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WYE 354-d3 Suppliers
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
1794791-66-4, WYE 354-d3Related Search:
WYE-354
N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea
WYE-687