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KRN 633

Product Name
KRN 633
CAS No.
286370-15-8
Chemical Name
KRN 633
Synonyms
CS-463;KRN 633;KRN 633;KRN-633;KRN 633 USP/EP/BP;KRN633; KRN-633; KRN 633;VEGFR Tyrosine Kinase Inhibitor III, KRN633;KRN 633 (This product is unavailable in the U.S.);1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea;N-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N'-propylurea;N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea
CBNumber
CB42561482
Molecular Formula
C20H21ClN4O4
Formula Weight
416.86
MOL File
286370-15-8.mol
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KRN 633 Property

Melting point:
231-232°C
Boiling point:
545.6±50.0 °C(Predicted)
Density 
1.321
storage temp. 
-20°C
solubility 
DMSO: soluble3mg/mL, clear (warmed)
pka
13.08±0.70(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0957
Product name
KRN633
Purity
≥98% (HPLC)
Packaging
5mg
Price
$133
Updated
2022/05/15
Cayman Chemical
Product number
14871
Product name
KRN 633
Purity
≥95%
Packaging
1mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
14871
Product name
KRN 633
Purity
≥95%
Packaging
5mg
Price
$99
Updated
2024/03/01
Cayman Chemical
Product number
14871
Product name
KRN 633
Purity
≥95%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
14871
Product name
KRN 633
Purity
≥95%
Packaging
50mg
Price
$773
Updated
2024/03/01
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KRN 633 Chemical Properties,Usage,Production

Uses

KRN 633 is an ATP-competitive inhibitor of VEGFR1/2/3 with IC50 of 170 nM/160 nM/125 nM and also inhibits PDGFRα/β with IC50 of 965 nM/9850 nM.

Uses

KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.

Biological Activity

krn 633 is a selective inhibitor of vegfr-1, vegfr-2 and vegfr-3 with ic50 value of 170 nm, 160 nm and 125 nm [1].vascular endothelial growth factor receptor (vegfr) is a protein and plays an important role in tumor angiogenesis by cooperating with its ligand vegf [1].krn 633 is a potent vegfr inhibitor. when tested with huvecs, krn 633 inhibited the cell proliferation that mediated by vegf with the ic50 value of 14.9 nmol/l and suppressed the capillary tube formation by ~50% at the dose of 10 nmol/l [1].in mid-pregnant mice model, krn633 was used at the dose of 5 mg/kg once daily from embryonic day 13.5 until the day of delivery and the effect on vascular growth was slightly delayed on postnatal day 4 (p4) and on p8 it was observed that krn633 resulted in the decreased numbers of central arteries and veins and abnormal branching of the central arteries [2]. when tested with athymic mouse xenograft ht29 cells model, administration of krn633 inhibited tumor growth as ~90% from the initial tumor volume rangs from 500-667 mm3, while had less effect du145 xenograft mouse models by inhibiting tumor angiogenesis and vascular permeability [1].

Biochem/physiol Actions

KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC50 values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only at higher concentrations (IC50 = 0.97 and 4.33 μM, respectively) and is inactive towards a panel of 17 other kinases (IC50 >/= 10 μM).

target

VEGFR3

References

[1]. nakamura, k., et al., krn633: a selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. mol cancer ther, 2004. 3(12): p. 1639-49.
[2]. morita, a., et al., treatment of mid-pregnant mice with krn633, an inhibitor of vascular endothelial growth factor receptor tyrosine kinase, induces abnormal retinal vascular patterning in their newborn pups. birth defects res b dev reprod toxicol, 2014. 101(4): p. 293-9.

KRN 633 Preparation Products And Raw materials

Raw materials

Preparation Products

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KRN 633 Suppliers

China 93 Europe 1 India 3 Japan 1 United States 19 Global 117
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
ProdList
2782
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58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
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58
ApexBio Technology
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sales@apexbt.com
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United States
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58
Cayman Chemical Company
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--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
United States Biological
Tel
--
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Email
chemicals@usbio.net
Country
United States
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6214
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Creative Enzymes
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info@creative-enzymes.com
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6057
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MedChemExpress
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Combi-Blocks Inc.
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Riedel-de Haen AG
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Matrix Scientific
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sales@matrixscientific.com
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6632
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Santa Cruz Biotechnology, Inc.
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scbt@scbt.com
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SynInnova Laboratories Inc.
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sales@syninnova.com
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Selleck Chemicals LLC
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--
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info@selleckchem.com
Country
United States
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824
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View Lastest Price from KRN 633 manufacturers

Career Henan Chemical Co
Product
KRN 633 286370-15-8
Price
US $1000.00-950.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100kg
Release date
2018-08-04

286370-15-8, KRN 633Related Search:

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  • KRN 633
  • N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea
  • 1-(2-chloro-4-(6,7-diMethoxyquinazolin-4-yloxy)phenyl)-3-propylurea
  • N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propylurea KRN633
  • VEGFR Tyrosine Kinase Inhibitor III, KRN633
  • KRN 633;KRN-633
  • CS-463
  • KRN633; KRN-633; KRN 633
  • Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-
  • KRN 633 (This product is unavailable in the U.S.)
  • KRN 633 USP/EP/BP
  • N-[2-Chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl]-N'-propylurea
  • 286370-15-8
  • Inhibitors