SU 11274
- Product Name
- SU 11274
- CAS No.
- 658084-23-2
- Chemical Name
- SU 11274
- Synonyms
- 1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-;Sul1274;PKI-SU11274;SU 11274, >=98%;SU 11274,SU 11274;SU 11274 USP/EP/BP;Met Kinase Inhibitor;SU11274(PKI-SU11274);SU-11274;PKI-SU11274;SU 11274;Met Kinase Inhibitor SU11274 SU-11274
- CBNumber
- CB3504776
- Molecular Formula
- C28H30ClN5O4S
- Formula Weight
- 568.09
- MOL File
- 658084-23-2.mol
SU 11274 Property
- Density
- 1.401±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 10 mg/mL at 60 °C
- pka
- 11.62±0.20(Predicted)
- form
- powder
- color
- orange
- InChIKey
- FPYJSJDOHRDAMT-KQWNVCNZSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 448101
- Product name
- Met Kinase Inhibitor
- Packaging
- 1mg
- Price
- $154
- Updated
- 2023/06/20
- Product number
- 14861
- Product name
- SU 11274
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 14861
- Product name
- SU 11274
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- S9820
- Product name
- SU 11274
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $921
- Updated
- 2022/05/15
- Product number
- 14861
- Product name
- SU 11274
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $130
- Updated
- 2024/03/01
SU 11274 Chemical Properties,Usage,Production
Description
MET is a proto-
Uses
SU 11274 is a competitive inhibitor of Met kinase activity.
Definition
ChEBI: 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- is a sulfonamide.
Biochem/physiol Actions
SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2
References
[1] wang x1, le p, liang c, chan j, kiewlich d, miller t, harris d, sun l, rice a, vasile s, blake ra, howlett ar, patel n, mcmahon g, lipson ke. potent and selective inhibitors of the met [hepatocyte growth factor/scatter factor (hgf/sf) receptor] tyrosine kinase block hgf/sf-induced tumor cell growth and invasion. mol cancer ther. 2003 nov;2(11):1085-92.
[2] leiser d1, pochon b1, blank-liss w1, francica p1, glück aa1, aebersold dm1, zimmer y1, medová m2. targeting of the met receptor tyrosine kinase by small molecule inhibitors leads to met accumulation by impairing the receptor downregulation. febs lett. 2014 mar 3;588(5):653-8.
SU 11274 Preparation Products And Raw materials
Raw materials
Preparation Products
SU 11274 Suppliers
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View Lastest Price from SU 11274 manufacturers
- Product
- (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide 658084-23-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-23
- Product
- (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide 658084-23-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-20