SU 5205
- Product Name
- SU 5205
- CAS No.
- 3476-86-6
- Chemical Name
- SU 5205
- Synonyms
- SU 5205;SU5205, 10 mM in DMSO;SU 5205; SU-5205; SU5205;(z)-3-(4-fluorobenzylidene)indolin-2-one;2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-;mitogenesis,Inhibitor,VEGFR2,Vascular endothelial growth factor receptor,FLK-1,SU-5205,endothelial,VEGFR,SU5205,inhibit
- CBNumber
- CB13123194
- Molecular Formula
- C15H10FNO
- Formula Weight
- 239.24
- MOL File
- 3476-86-6.mol
SU 5205 Property
- Melting point:
- 194-196 °C
- Boiling point:
- 435.3±45.0 °C(Predicted)
- Density
- 1.306±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml
- form
- A crystalline solid
- pka
- 12.69±0.20(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 27310
- Product name
- SU 5205
- Packaging
- 100mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 27310
- Product name
- SU 5205
- Packaging
- 250mg
- Price
- $199
- Updated
- 2024/03/01
- Product number
- 27310
- Product name
- SU 5205
- Packaging
- 50mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- AS553614
- Product name
- Su5205
- Purity
- 97%
- Packaging
- 5mg
- Price
- $28
- Updated
- 2021/12/16
- Product number
- AS553614
- Product name
- Su5205
- Purity
- 97%
- Packaging
- 10mg
- Price
- $37
- Updated
- 2021/12/16
SU 5205 Chemical Properties,Usage,Production
Uses
SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].
Biological Activity
SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM.
Synthesis
59-48-3
459-57-4
3476-86-6
GENERAL STEPS: 2-Indolone (1 eq.) and p-fluorobenzaldehyde (1 eq.) were added to ethanol (EtOH, 3 mL/0.2 mmol) and the mixture was stirred until completely dissolved. Subsequently piperidine (0.1 eq.) was added and the reaction mixture was heated to 90 °C and kept reacting for 3-7 hours. After completion of the reaction, it was cooled to room temperature. The resulting precipitate was collected by filtration, washed with cold ethanol and dried to give 3-(4-fluorophenylmethylene)indolin-2-one crude. If further purity is required, the product can be purified by ethanol recrystallization.
in vitro
SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC 50 of 5.1 μM.
target
| Target | Value |
| VEGFR2 (Cell-free assay) | 9.6 μM |
IC 50
Flk-1: 9.6 μM (IC50)
References
[1] Huh S, et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull. 2010;33(7):1242-5. DOI:10.1248/bpb.33.1242
[2] Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.
SU 5205 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SU 5205 manufacturers
- Product
- SU 5205 3476-86-6
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-01