SU 5416

Product Name: SU 5416
CAS No.: 204005-46-9
Chemical Name: SU 5416
Synonyms: 17022;SU54161;SeMaxinib;(Z)-3-((3;Sugen 5416;SU5416 /SU-5416;SU 5416 semaxanib;SEMAXINIB(SU 5416);SU 5416 (SeMaxinib);SEMAXINIB; SU-5416; SU 5416
CBNumber: CB8504771
Molecular Formula: C15H14N2O
Formula Weight: 238.28
MOL File: 204005-46-9.mol

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SU 5416 Property

Melting point:: 226-228 °C
Boiling point:: 481.4±45.0 °C(Predicted)
Density: 1.256±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: H₂O: insoluble
form: Yellow orange solid
pka: 12.59±0.20(Predicted)
color: yellow to yellow orange

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S8442
Product name: SU 5416
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $162
Updated: 2024/03/01

Cayman Chemical

Product number: 13342
Product name: SU 5416
Purity: ≥98%
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Sigma-Aldrich

Product number: S8442
Product name: SU 5416
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $560
Updated: 2024/03/01

Cayman Chemical

Product number: 13342
Product name: SU 5416
Purity: ≥98%
Packaging: 25mg
Price: $289
Updated: 2024/03/01

Cayman Chemical

Product number: 13342
Product name: SU 5416
Purity: ≥98%
Packaging: 50mg
Price: $547
Updated: 2024/03/01

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SU 5416 Chemical Properties,Usage,Production

Uses

SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.

Uses

SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.³ It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.⁴

Definition

ChEBI: Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis modulating agent. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole.

Biological Activity

Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.

Biochem/physiol Actions

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2

storage

Desiccate at -20°C

SU 5416 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 5416 Suppliers

Canada 1 China 137 India 2 Switzerland 1 United Kingdom 2 United States 14 Global 157

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
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Shanghai Boyle Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
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GL Biochem (Shanghai) Ltd

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WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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VDM Biochemicals

Tel: 0330-2528181
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Syntechem Co.,Ltd

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BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
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View Lastest Price from SU 5416 manufacturers

Career Henan Chemical Co

Product: SU 5416 204005-46-9
Price: US $5.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-09-03

204005-46-9, SU 5416Related Search:

SU 6656 N,N-Dimethylaniline 5,5-Dimethylhydantoin 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU5402 N-Desethyl Sunitinib SU 9516 SU 5205 SU4312 VEGFR2 Kinase Inhibitor I SU5208 SU 11274 Sunitinib Malate Sunitinib PHA-665752 SU 5416 N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide SUNITINIB-D10

(3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

SEMAXINIB; SU-5416; SU 5416

(E)-3-((3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLENE)INDOLIN-2-ONE

VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem

5-Dimethyl-1H-pyrrol-2-yl)met hylene)indolin-2-one

(Z)-3-((3

SU5416; SU-5416; SU 5416; SUGEN 5416; SEMOXIND; SEMAXANIB

Sugen 5416

H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-

SeMaxinib

SU 5416 (SeMaxinib)

SU5416 /SU-5416

(Z)-3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one

3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one

3-[(3,5-diMethyl-1H-pyrrol-2-yl)Methylidene]-1H-indol-2-one

SEMAXINIB(SU 5416)

3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one

VEGFR2 Kinase Inhibitor III

3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-on

17022

3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one

SU 5416, 98%, a VEGFR2/Flk1 inhibitor

SU 5416 semaxanib

SU54161

2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-

204005-46-9

Angiogenesis and Metastasis

Inhibitors