SU 6656
- Product Name
- SU 6656
- CAS No.
- 330161-87-0
- Chemical Name
- SU 6656
- Synonyms
- CS-1672;SU 6656;SU-6656;SU6656 - CAS 330161-87-0 - Calbiochem;N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide;N,N-Dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide;2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-;PTK2 protein tyrosine kinase 2,Focal adhesion kinase,FAK,Akt,SU-6656,PTK2,Inhibitor,Protein kinase B,SU 6656,SU6656,Src,PKB,inhibit
- CBNumber
- CB0504775
- Molecular Formula
- C19H21N3O3S
- Formula Weight
- 371.45
- MOL File
- 330161-87-0.mol
SU 6656 Property
- Density
- 1.378±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: 12 mg/mL orange solution
- pka
- 11.87±0.20(Predicted)
- form
- powder
- color
- orange-brown
- InChIKey
- LOGJQOUIVKBFGH-YBEGLDIGSA-N
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- S9692
- Product name
- SU 6656
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $66
- Updated
- 2024/03/01
- Product number
- 572635
- Product name
- SU6656
- Packaging
- 1mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 13338
- Product name
- SU6656
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2024/03/01
- Product number
- 13338
- Product name
- SU6656
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- S9692
- Product name
- SU 6656
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $660
- Updated
- 2024/03/01
SU 6656 Chemical Properties,Usage,Production
Description
The Src family of proto-
Uses
SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death.
Uses
The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.
General Description
A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC50 ≥10 μM) and IGF-1 receptor kinase (IC50 ≥20 μM).
Biochem/physiol Actions
Cell permeable: yes
in vivo
su6656 administered prior to irradiation significantly promotes radiation-induced destruction of blood vessels within the tumor windows. it also facilitates tumor growth delay when administered during fractionated irradiation. [3]
storage
Store at -20°C
References
1. blake ra, broome ma, liu x et al. su6656, a selective src family kinase inhibitor, used to probe growth factor signaling. mol cell biol. 2000 dec;20(23):9018-27.2. lannutti bj, blake n, gandhi mj et al. induction of polyploidization in leukemic cell lines and primary bone marrow by src kinase inhibitor su6656. blood. 2005 may 15;105(10):3875-8.3. cuneo kc, geng l, tan j et al. src family kinase inhibitor su6656 enhances antiangiogenic effect of irradiation. int j radiat oncol biol phys. 2006 mar 15;64(4):1197-203.
SU 6656 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SU 6656 manufacturers
- Product
- SU6656 330161-87-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30