ChemicalBook > CAS DataBase List > SU 6656

SU 6656

Product Name: SU 6656
CAS No.: 330161-87-0
Chemical Name: SU 6656
Synonyms: CS-1672;SU6656 ，S7774;SU 6656;SU-6656;SU6656, 10 mM in DMSO;SU6656 - CAS 330161-87-0 - Calbiochem;N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide;N,N-Dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide;2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-;PTK2 protein tyrosine kinase 2,Focal adhesion kinase,FAK,Akt,SU-6656,PTK2,Inhibitor,Protein kinase B,SU 6656,SU6656,Src,PKB,inhibit
CBNumber: CB0504775
Molecular Formula: C19H21N3O3S
Formula Weight: 371.45
MOL File: 330161-87-0.mol

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SU 6656 Property

Density: 1.378±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: 12 mg/mL orange solution
pka: 11.87±0.20(Predicted)
form: powder
color: orange-brown
InChIKey: LOGJQOUIVKBFGH-YBEGLDIGSA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S9692
Product name: SU 6656
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $161.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 572635
Product name: SU6656
Packaging: 1mg
Price: $222
Updated: 2025/07/31

Cayman Chemical

Product number: 13338
Product name: SU6656
Purity: ≥95%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 13338
Product name: SU6656
Purity: ≥95%
Packaging: 5mg
Price: $94
Updated: 2024/03/01

Sigma-Aldrich

Product number: S9692
Product name: SU 6656
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $679
Updated: 2025/07/31

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SU 6656 Chemical Properties,Usage,Production

Description

The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC₅₀ = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.

Uses

SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death.

Uses

The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.

General Description

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ ≥10 μM) and IGF-1 receptor kinase (IC₅₀ ≥20 μM).

Biochem/physiol Actions

Cell permeable: yes

in vivo

su6656 administered prior to irradiation significantly promotes radiation-induced destruction of blood vessels within the tumor windows. it also facilitates tumor growth delay when administered during fractionated irradiation. [3]

storage

Store at -20°C

References

1. blake ra, broome ma, liu x et al. su6656, a selective src family kinase inhibitor, used to probe growth factor signaling. mol cell biol. 2000 dec;20(23):9018-27.2. lannutti bj, blake n, gandhi mj et al. induction of polyploidization in leukemic cell lines and primary bone marrow by src kinase inhibitor su6656. blood. 2005 may 15;105(10):3875-8.3. cuneo kc, geng l, tan j et al. src family kinase inhibitor su6656 enhances antiangiogenic effect of irradiation. int j radiat oncol biol phys. 2006 mar 15;64(4):1197-203.

SU 6656 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SU 6656 manufacturers

Career Henan Chemical Co

Product: SU6656 330161-87-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-30

330161-87-0, SU 6656Related Search:

SU 5416 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU 9516 SU 6656

SU6656 - CAS 330161-87-0 - Calbiochem

SU 6656;SU-6656

CS-1672

N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide

2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide

1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-

PTK2 protein tyrosine kinase 2,Focal adhesion kinase,FAK,Akt,SU-6656,PTK2,Inhibitor,Protein kinase B,SU 6656,SU6656,Src,PKB,inhibit

N,N-Dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide

SU6656, 10 mM in DMSO

SU6656 ，S7774

330161-87-0