ChemicalBook > CAS DataBase List > SU 6656

SU 6656

Product Name
SU 6656
CAS No.
330161-87-0
Chemical Name
SU 6656
Synonyms
CS-1672;SU 6656;SU-6656;SU6656 - CAS 330161-87-0 - Calbiochem;N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide;N,N-Dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide;2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide;1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-;PTK2 protein tyrosine kinase 2,Focal adhesion kinase,FAK,Akt,SU-6656,PTK2,Inhibitor,Protein kinase B,SU 6656,SU6656,Src,PKB,inhibit
CBNumber
CB0504775
Molecular Formula
C19H21N3O3S
Formula Weight
371.45
MOL File
330161-87-0.mol
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SU 6656 Property

Density 
1.378±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: 12 mg/mL orange solution
pka
11.87±0.20(Predicted)
form 
powder
color 
orange-brown
InChIKey
LOGJQOUIVKBFGH-YBEGLDIGSA-N
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S9692
Product name
SU 6656
Purity
≥98% (HPLC)
Packaging
5mg
Price
$66
Updated
2024/03/01
Sigma-Aldrich
Product number
572635
Product name
SU6656
Packaging
1mg
Price
$216
Updated
2024/03/01
Cayman Chemical
Product number
13338
Product name
SU6656
Purity
≥95%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
13338
Product name
SU6656
Purity
≥95%
Packaging
5mg
Price
$94
Updated
2024/03/01
Sigma-Aldrich
Product number
S9692
Product name
SU 6656
Purity
≥98% (HPLC)
Packaging
25mg
Price
$660
Updated
2024/03/01
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SU 6656 Chemical Properties,Usage,Production

Description

The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.

Uses

SU 6656 is a small molecule selective inhibitor of the Src kinase family and induces caspase-independant cancer cell death.

Uses

The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly inhibits some other kinases when used at >10 μM. SU6656 has been used to study the role of Src kinases in cell growth and development in diverse processes, including nervous system development, fibrosis, and cancer.

General Description

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC50 = 280 nM) as well as closely related kinases Fyn (IC50 = 170 nM), Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC50 = 6.88 μM). Does not affect the activity of PDGF-β receptor kinase (IC50 ≥10 μM) and IGF-1 receptor kinase (IC50 ≥20 μM).

Biochem/physiol Actions

Cell permeable: yes

in vivo

su6656 administered prior to irradiation significantly promotes radiation-induced destruction of blood vessels within the tumor windows. it also facilitates tumor growth delay when administered during fractionated irradiation. [3]

storage

Store at -20°C

References

1. blake ra, broome ma, liu x et al. su6656, a selective src family kinase inhibitor, used to probe growth factor signaling. mol cell biol. 2000 dec;20(23):9018-27.2. lannutti bj, blake n, gandhi mj et al. induction of polyploidization in leukemic cell lines and primary bone marrow by src kinase inhibitor su6656. blood. 2005 may 15;105(10):3875-8.3. cuneo kc, geng l, tan j et al. src family kinase inhibitor su6656 enhances antiangiogenic effect of irradiation. int j radiat oncol biol phys. 2006 mar 15;64(4):1197-203.

SU 6656 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 6656 Suppliers

China 74 India 1 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 13 Global 92
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from SU 6656 manufacturers

Career Henan Chemical Co
Product
SU6656 330161-87-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-30

330161-87-0, SU 6656Related Search:

SU 5416 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU 9516 SU 6656

  • SU6656 - CAS 330161-87-0 - Calbiochem
  • SU 6656;SU-6656
  • CS-1672
  • N,N-diMethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)Methyl)indoline-5-sulfonaMide
  • 2,3-dihydro-n,n-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1h-indol-2-yl)methylene]-1h-indole-5-sulfonamide
  • 1H-Indole-5-sulfonamide, 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-
  • PTK2 protein tyrosine kinase 2,Focal adhesion kinase,FAK,Akt,SU-6656,PTK2,Inhibitor,Protein kinase B,SU 6656,SU6656,Src,PKB,inhibit
  • N,N-Dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)indoline-5-sulfonamide
  • 330161-87-0