ChemicalBook > CAS DataBase List > SU 5416

SU 5416

Product Name
SU 5416
CAS No.
204005-46-9
Chemical Name
SU 5416
Synonyms
17022;SU54161;SeMaxinib;(Z)-3-((3;Sugen 5416;SU5416 /SU-5416;SU 5416 semaxanib;SEMAXINIB(SU 5416);SU 5416 (SeMaxinib);SEMAXINIB; SU-5416; SU 5416
CBNumber
CB8504771
Molecular Formula
C15H14N2O
Formula Weight
238.28
MOL File
204005-46-9.mol
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SU 5416 Property

Melting point:
226-228 °C
Boiling point:
481.4±45.0 °C(Predicted)
Density 
1.256±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: insoluble
form 
Yellow orange solid
pka
12.59±0.20(Predicted)
color 
yellow to yellow orange
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S8442
Product name
SU 5416
Purity
≥98% (HPLC)
Packaging
5mg
Price
$162
Updated
2024/03/01
Cayman Chemical
Product number
13342
Product name
SU 5416
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
Sigma-Aldrich
Product number
S8442
Product name
SU 5416
Purity
≥98% (HPLC)
Packaging
25mg
Price
$560
Updated
2024/03/01
Cayman Chemical
Product number
13342
Product name
SU 5416
Purity
≥98%
Packaging
25mg
Price
$289
Updated
2024/03/01
Cayman Chemical
Product number
13342
Product name
SU 5416
Purity
≥98%
Packaging
50mg
Price
$547
Updated
2024/03/01
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SU 5416 Chemical Properties,Usage,Production

Uses

SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.

Uses

SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.3 It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.4

Definition

ChEBI: Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis modulating agent. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole.

Biological Activity

Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.

Biochem/physiol Actions

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2

storage

Desiccate at -20°C

SU 5416 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 5416 Suppliers

Canada 1 China 141 India 2 Switzerland 1 United Kingdom 2 United States 14 Global 161
Tianjin Kailiqi Biotechnology Co., Ltd.
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View Lastest Price from SU 5416 manufacturers

Career Henan Chemical Co
Product
SU 5416 204005-46-9
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

204005-46-9, SU 5416Related Search:

SU 6656 N,N-Dimethylaniline 5,5-Dimethylhydantoin 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU5402 N-Desethyl Sunitinib SU 9516 SU 5205 SU4312 VEGFR2 Kinase Inhibitor I SU5208 SU 11274 Sunitinib Malate Sunitinib PHA-665752 SU 5416 N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide SUNITINIB-D10

  • (3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
  • SEMAXINIB; SU-5416; SU 5416
  • (E)-3-((3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLENE)INDOLIN-2-ONE
  • VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem
  • 5-Dimethyl-1H-pyrrol-2-yl)met hylene)indolin-2-one
  • (Z)-3-((3
  • SU5416; SU-5416; SU 5416; SUGEN 5416; SEMOXIND; SEMAXANIB
  • Sugen 5416
  • H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-
  • SeMaxinib
  • SU 5416 (SeMaxinib)
  • SU5416 /SU-5416
  • (Z)-3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one
  • 3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one
  • 3-[(3,5-diMethyl-1H-pyrrol-2-yl)Methylidene]-1H-indol-2-one
  • SEMAXINIB(SU 5416)
  • 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
  • VEGFR2 Kinase Inhibitor III
  • 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-on
  • 17022
  • 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one
  • SU 5416, 98%, a VEGFR2/Flk1 inhibitor
  • SU 5416 semaxanib
  • SU54161
  • 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-
  • 204005-46-9
  • Angiogenesis and Metastasis
  • Inhibitors