ChemicalBook > CAS DataBase List > SU 5416

SU 5416

Product Name
SU 5416
CAS No.
204005-46-9
Chemical Name
SU 5416
Synonyms
17022;SU54161;SeMaxinib;(Z)-3-((3;Sugen 5416;SU5416 /SU-5416;SU 5416 semaxanib;SEMAXINIB(SU 5416);SU 5416 (SeMaxinib);SEMAXINIB; SU-5416; SU 5416
CBNumber
CB8504771
Molecular Formula
C15H14N2O
Formula Weight
238.28
MOL File
204005-46-9.mol
More
Less

SU 5416 Property

Melting point:
226-228 °C
Boiling point:
481.4±45.0 °C(Predicted)
Density 
1.256±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
H2O: insoluble
form 
Yellow orange solid
pka
12.59±0.20(Predicted)
color 
yellow to yellow orange
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S8442
Product name
SU 5416
Purity
≥98% (HPLC)
Packaging
5mg
Price
$162
Updated
2024/03/01
Cayman Chemical
Product number
13342
Product name
SU 5416
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
Sigma-Aldrich
Product number
S8442
Product name
SU 5416
Purity
≥98% (HPLC)
Packaging
25mg
Price
$560
Updated
2024/03/01
Cayman Chemical
Product number
13342
Product name
SU 5416
Purity
≥98%
Packaging
25mg
Price
$289
Updated
2024/03/01
Cayman Chemical
Product number
13342
Product name
SU 5416
Purity
≥98%
Packaging
50mg
Price
$547
Updated
2024/03/01
More
Less

SU 5416 Chemical Properties,Usage,Production

Uses

SU 5416 is a vascular endothelial growth factor receptor blocker that may induce severe pulmonary hypertension if combined with chronic hypoxia. Angiogenesis inhibitor used for deep penetration into tumor tissues.

Uses

SU 516 was used to study the mechanism of development of cerebral vasculature in zebrafish hindbrain.3 It was used to study the pulmonary vascular remodeling in response to hypoxia in mouse model of pulmonary arterial hypertension.4

Definition

ChEBI: Semaxanib is an oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is replaced by a 3,5-dimethylpyrrol-2-yl group. It has a role as an antineoplastic agent, a vascular endothelial growth factor receptor antagonist, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an angiogenesis modulating agent. It is a member of pyrroles, a member of oxindoles and an olefinic compound. It is functionally related to a 3-methyleneoxindole.

Biological Activity

Inhibitor of vascular endothelial growth factor receptor (VEGFR) that also inhibits other tyrosine kinases KIT, MET, FLT3 and RET. Displays no activity against EGFR, HER2, IGF1R and PDGFR. Inhibits tumor vascularization and growth of multiple tumor types.

Biochem/physiol Actions

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.1 It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.2

storage

Desiccate at -20°C

SU 5416 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SU 5416 Suppliers

Canada 1 China 138 India 2 Switzerland 1 United Kingdom 2 United States 14 Global 158
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
3501
Advantage
55
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
ZHIWE CHEMTECH CO LTD
Tel
021-20221225 13917446399
Fax
QQ:115820162
Email
sales@zhiwe.net
Country
China
ProdList
579
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
918
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12990
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9901
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25014
Advantage
65
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2867
Advantage
52
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7854
Advantage
58
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3423
Advantage
58
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9986
Advantage
55
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13359
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15185
Advantage
58
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5738
Advantage
55
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15885
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
AN PharmaTech Co Ltd
Tel
86(21)68097365
Fax
86(21)33321566
Email
sales@anpharma.net
Country
China
ProdList
4901
Advantage
55
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3988
Advantage
60
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9254
Advantage
55
ELSA BIOTECHNOLOGY CO.,LTD.
Tel
15261860116
Fax
86-025-84106591
Email
sales@elsa-biotech.com
Country
China
ProdList
99
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9638
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3868
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27322
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9934
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
order@changyanchem.com
Country
China
ProdList
5008
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9604
Advantage
55
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14623
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
21-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2989
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9779
Advantage
58
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29796
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131980
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7183
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7580
Advantage
55
More
Less

View Lastest Price from SU 5416 manufacturers

Career Henan Chemical Co
Product
SU 5416 204005-46-9
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

204005-46-9, SU 5416Related Search:

SU 6656 N,N-Dimethylaniline 5,5-Dimethylhydantoin 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU5402 N-Desethyl Sunitinib SU 9516 SU 5205 SU4312 VEGFR2 Kinase Inhibitor I SU5208 SU 11274 Sunitinib Malate Sunitinib PHA-665752 SU 5416 N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide SUNITINIB-D10

  • (3Z)-3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
  • SEMAXINIB; SU-5416; SU 5416
  • (E)-3-((3,5-DIMETHYL-1H-PYRROL-2-YL)METHYLENE)INDOLIN-2-ONE
  • VEGFR2 Kinase Inhibitor III - CAS 204005-46-9 - Calbiochem
  • 5-Dimethyl-1H-pyrrol-2-yl)met hylene)indolin-2-one
  • (Z)-3-((3
  • SU5416; SU-5416; SU 5416; SUGEN 5416; SEMOXIND; SEMAXANIB
  • Sugen 5416
  • H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-
  • SeMaxinib
  • SU 5416 (SeMaxinib)
  • SU5416 /SU-5416
  • (Z)-3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one
  • 3-((3,5-diMethyl-1H-pyrrol-2-yl)Methylene)indolin-2-one
  • 3-[(3,5-diMethyl-1H-pyrrol-2-yl)Methylidene]-1H-indol-2-one
  • SEMAXINIB(SU 5416)
  • 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
  • VEGFR2 Kinase Inhibitor III
  • 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-on
  • 17022
  • 3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-indolin-2-one
  • SU 5416, 98%, a VEGFR2/Flk1 inhibitor
  • SU 5416 semaxanib
  • SU54161
  • 2H-Indol-2-one, 3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-
  • 204005-46-9
  • Angiogenesis and Metastasis
  • Inhibitors