N-Desethyl Sunitinib

Product Name: N-Desethyl Sunitinib
CAS No.: 356068-97-8
Chemical Name: N-Desethyl Sunitinib
Synonyms: SU11662;HY-10873;SU-11662;SU 11662;N-Desethyl Sunitinib;Sunitinib N-Desethyl Imp;SU11662;SU 11662;SU-11662;N-Desethylsunitinib TFA Salt;Sunitinib N-Desethyl Impurity;Sunitinib Des Ethyl Impurity-A
CBNumber: CB11565651
Molecular Formula: C20H23FN4O2
Formula Weight: 370.42
MOL File: 356068-97-8.mol

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N-Desethyl Sunitinib Property

Melting point:: 268-270?C
Boiling point:: 574.4±50.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly, Heated), Methanol (Sparingly)
form: Solid
pka: 11.71±0.20(Predicted)
color: Yellow to Dark Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3117
Product name: N-Desethyl sunitinib hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $142
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML3117
Product name: N-Desethyl sunitinib hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $456
Updated: 2023/06/20

Cayman Chemical

Product number: 22292
Product name: N-desethyl Sunitinib
Purity: ≥98%
Packaging: 500μg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 22292
Product name: N-desethyl Sunitinib
Purity: ≥98%
Packaging: 1mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 22292
Product name: N-desethyl Sunitinib
Purity: ≥98%
Packaging: 5mg
Price: $283
Updated: 2024/03/01

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N-Desethyl Sunitinib Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

A metabolite of Sunitinib (S820000).

Biological Activity

N-Desethyl sunitinib is a multi-target tyrosine kinase inhibitor th at is a major active metabolite of an anticancer drug sunitinib. N-Desethyl sunitinib has a similar kinase inhibitory effect as sunitinib. In patients, plasma sunitinib and N-desethyl sunitinib accounts for 42% and 24%, respectively. Thus N-desethyl sunitinib accounts for one third of the therapeutic effect of oral sunitinib.

N-Desethyl Sunitinib Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Desethyl Sunitinib Suppliers

Canada 1 China 79 India 4 United Kingdom 1 United States 12 Global 97

Aurisco Pharmaceutical (Tianjin) Inc.

Tel: 022-59885855
Country: China
ProdList: 96
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94657
Advantage: 76

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9478
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Clearsynth Labs Limited

Tel: +91-22-26355700
Fax: +91-22-26355701
Email: info@clearsynth.com
Country: India
ProdList: 9679
Advantage: 58

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1955
Advantage: 55

356068-97-8, N-Desethyl SunitinibRelated Search:

N,N-Dimethyl Sunitinib N-Desethylsunitinib hydrochloride N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide SU 5416 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU 11274 SU5402 Lacosamide De-5-fluoro 4-FluorochidaMide 2,4-DIMETHYL PYRROL-3-CARBALDEHYDE Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 5-Fluoro-2-oxindole Pyrrole-2,4-dicarboxaldehyde, 3,5-dimethyl- (6CI,7CI,8CI) Sunitinib iMpurity Sunitinib N-Oxide Sunitinib Malate Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-[2-(Ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-Desethyl Sunitinib

SU 11662

SU11662

SU-11662

HY-10873

5-[((3Z)-5-Fluoro-2-oxo-1,2-dihydroindol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)amide

N-Desethyl Sunitinib/(Z)-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

SU11662;SU 11662;SU-11662

Sunitinib N-Desethyl Imp

N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

Sunitinib N-Desethyl Impurity

1H-Pyrrole-3-carboxamide, N-[2-(ethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-

(Z)-N-(2-(ethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-Desethyl Sunitinib DISCONTINUED

N-Desethyl Sunitinib (SU-11662)

N-Desethylsunitinib TFA Salt

N-Desethyl Sunitinib (Sunitinib Impurity)

Sunitinib Des Ethyl Impurity-A

356068-97-8

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Tyrosine Kinase Inhibitors

Pfizer compounds