Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
- Product Name
- Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
- CAS No.
- 2199-51-1
- Chemical Name
- Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
- Synonyms
- Sunitinib Impurity 28;Sunitinib Impurity 41;Sunitinib malate INT III;Ethyl 2,4-diMethyl-1H-pyr...;4-dimethyl-1H-pyrrole-3-carboxylate;ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE;Ethyl2,4-Dimethylpyrrole-3-carboxylate>2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole;Ethyl 2,4-dimethyl-1H-pyrrol-3-carboxylate;thyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
- CBNumber
- CB1696136
- Molecular Formula
- C9H13NO2
- Formula Weight
- 167.21
- MOL File
- 2199-51-1.mol
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Property
- Melting point:
- 122-123°C
- Boiling point:
- 162°C/11mmHg(lit.)
- Density
- 1.1222 (rough estimate)
- refractive index
- 1.4680 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Soluble), Chloroform (Slightly), Methanol (Slightly)
- pka
- 16.44±0.50(Predicted)
- form
- Solid
- color
- Red to Very Dark Red
- λmax
- 258nm(EtOH)(lit.)
- InChI
- InChI=1S/C9H13NO2/c1-4-12-9(11)8-6(2)5-10-7(8)3/h5,10H,4H2,1-3H3
- InChIKey
- QWSFDUPEOPMXCV-UHFFFAOYSA-N
- SMILES
- N1C=C(C)C(C(OCC)=O)=C1C
- CAS DataBase Reference
- 2199-51-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester(2199-51-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-45-22
- Hazard Note
- Irritant
- HS Code
- 29337900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H341Suspected of causing genetic defects
H350May cause cancer
H360May damage fertility or the unborn child
H371May cause damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E1075
- Product name
- Ethyl 2,4-Dimethylpyrrole-3-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- E1075
- Product name
- Ethyl 2,4-Dimethylpyrrole-3-carboxylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $171
- Updated
- 2025/07/31
- Product number
- D477995
- Product name
- 2,4-Dimethyl-1H-pyrrole-3-carboxylicAcidEthylEster
- Packaging
- 10g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR9926
- Product name
- Ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $13
- Updated
- 2021/12/16
- Product number
- 4H23-1-Y8
- Product name
- Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Chemical Properties,Usage,Production
Chemical Properties
White to light brown crystalline
Uses
2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used in the preparation of blue pyrrole dyes. 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is also used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.
Uses
ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate is used in the preparation of blue pyrrole dyes. It is also used as an intermediate in the synt hesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.
Synthesis
86770-31-2
2199-51-1
Step (ii): Preparation of 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester In a 10-liter four-necked round-bottomed flask equipped with a mechanical stirrer, thermometer casing, gas introduction tube, and air condenser, 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester (II) (1.5 kg, 5.6 mol) and isopropanol (4.5 L) were added and stirred at 25-30 °C. Concentrated hydrochloric acid (2.2 L) was added slowly through the addition funnel. After addition, the reaction mixture was warmed up to 45-50 °C and maintained at this temperature until complete cessation of gas release. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solution was cooled to 25-30 °C and quenched in an ice-water bath. The product was separated by filtration and dried at 50 °C. A dried product of 721.3 g was obtained with 77.3% yield and >96% HPLC purity.
References
[1] Synlett, 2010, # 17, p. 2561 - 2564
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3062 - 3065
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 8578 - 8586
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 139 - 146
Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate manufacturers
- Product
- Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2021-11-20
- Product
- Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2023-03-01