ChemicalBook > CAS DataBase List > Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

Product Name: Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
CAS No.: 2199-51-1
Chemical Name: Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
Synonyms: Sunitinib Impurity 28;Sunitinib Impurity 41;Sunitinib malate INT III;Ethyl 2,4-diMethyl-1H-pyr...;4-dimethyl-1H-pyrrole-3-carboxylate;ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE;Ethyl2,4-Dimethylpyrrole-3-carboxylate>2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole;Ethyl 2,4-dimethyl-1H-pyrrol-3-carboxylate;thyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
CBNumber: CB1696136
Molecular Formula: C9H13NO2
Formula Weight: 167.21
MOL File: 2199-51-1.mol

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Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Property

Melting point:: 122-123°C
Boiling point:: 162°C/11mmHg(lit.)
Density: 1.1222 (rough estimate)
refractive index: 1.4680 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Soluble), Chloroform (Slightly), Methanol (Slightly)
pka: 16.44±0.50(Predicted)
form: Solid
color: Red to Very Dark Red
λmax: 258nm(EtOH)(lit.)
InChI: InChI=1S/C9H13NO2/c1-4-12-9(11)8-6(2)5-10-7(8)3/h5,10H,4H2,1-3H3
InChIKey: QWSFDUPEOPMXCV-UHFFFAOYSA-N
SMILES: N1C=C(C)C(C(OCC)=O)=C1C
CAS DataBase Reference: 2199-51-1(CAS DataBase Reference)
NIST Chemistry Reference: 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester(2199-51-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-45-22
Hazard Note: Irritant
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H341Suspected of causing genetic defects

H350May cause cancer

H360May damage fertility or the unborn child

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1075
Product name: Ethyl 2,4-Dimethylpyrrole-3-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: E1075
Product name: Ethyl 2,4-Dimethylpyrrole-3-carboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $171
Updated: 2025/07/31

TRC

Product number: D477995
Product name: 2,4-Dimethyl-1H-pyrrole-3-carboxylicAcidEthylEster
Packaging: 10g
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: OR9926
Product name: Ethyl2,4-dimethyl-1H-pyrrole-3-carboxylate
Purity: 97%
Packaging: 1g
Price: $13
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-Y8
Product name: Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
Purity: 98%
Packaging: 250mg
Price: $24
Updated: 2021/12/16

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Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Chemical Properties,Usage,Production

Chemical Properties

White to light brown crystalline

Uses

2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used in the preparation of blue pyrrole dyes. 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is also used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.

Uses

ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate is used in the preparation of blue pyrrole dyes. It is also used as an intermediate in the synt hesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.

Synthesis

86770-31-2

2199-51-1

Step (ii): Preparation of 2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester In a 10-liter four-necked round-bottomed flask equipped with a mechanical stirrer, thermometer casing, gas introduction tube, and air condenser, 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid 2-tert-butyl ester 4-ethyl ester (II) (1.5 kg, 5.6 mol) and isopropanol (4.5 L) were added and stirred at 25-30 °C. Concentrated hydrochloric acid (2.2 L) was added slowly through the addition funnel. After addition, the reaction mixture was warmed up to 45-50 °C and maintained at this temperature until complete cessation of gas release. The reaction progress was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solution was cooled to 25-30 °C and quenched in an ice-water bath. The product was separated by filtration and dried at 50 °C. A dried product of 721.3 g was obtained with 77.3% yield and >96% HPLC purity.

References

[1] Synlett, 2010, # 17, p. 2561 - 2564
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 3062 - 3065
[3] Journal of the American Chemical Society,
[4] Journal of the American Chemical Society, 2009, vol. 131, p. 8578 - 8586
[5] Journal of Medicinal Chemistry, 2010, vol. 53, # 1, p. 139 - 146

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 100kg
Release date: 2021-11-20

Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

Product: Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2199-51-1
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 98%+
Supply Ability: 100kg
Release date: 2023-03-01

2199-51-1, Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylateRelated Search:

N,N-Dimethylformamide Dimethyl sulfoxide N-Methyl-2-pyrrolidone 2,4-Dimethylpyrrole 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid ethyl ester 3,4-Dimethylaniline Polyvinylpyrrolidone Dimethyl carbonate RESMETHRIN Dimethyl sulfate ETHANE Pyrrole Dimethyl ether 2,4-Dimethyl aniline Dimethyl fumarate Dacthal 2,5-Dimethylpyrrolidine Povidone iodine

2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID ETHYL ESTER

ETHYL 2,4-DIMETHYL-1H-PYRROLE-3-CARBOXYLATE

ETHYL 2,4-DIMETHYL-PYRROLE-3-CARBOXYLATE

ETHYL 2,4-DIMETHYLPYRROLE-3-CARBOXYLIC ACID

1H-Pyrrole-3-carboxylic acid, 2,4-dimethyl-, ethyl ester

Sunitinib Impurity 28

Sunitinib malate INT III

Ethyl 2,4-dimethylpyrrole-3-carboxylate 98%

Pyrrole-3-carboxylic acid, 2,4-dimethyl-, ethyl ester

2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 98%

2,4-Dimethylpyrrole-3-carboxylic acid ethyl ester

Ethyl 2,4-diMethyl-1H-pyr...

Pyrrole-3-carboxylicacid, 2,4-diMethyl-, ethyl ester (6CI,7CI,8CI)

2,4-Dimethyl-3-(ethoxycarbonyl)-1H-pyrrole

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate 2,4-Dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylatethyl-1H-pyrrole-3-carboxylic acid

Ethyl2,4-Dimethylpyrrole-3-carboxylate&gt

4-dimethyl-1H-pyrrole-3-carboxylate

Sunitinib Impurity 41

Ethyl 2,4-dimethyl-1H-pyrrol-3-carboxylate

thyl 2,4-dimethyl-1H-pyrrole-3-carboxylate

2199-51-1

Sunitinib Intermediate

Intermediate of sunitinib malate

Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines

Pharmaceutial intermediates

2199-51-1