(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
- Product Name
- (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
- CAS No.
- 168835-82-3
- Chemical Name
- (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
- Synonyms
- CS-1481;CHEMBL261508;SU1498, >98%;SU1498 (AG 1498);Su1498, 10 mM in DMSO;Tyrphostin SU 1498, >98%;SU 1498, VEGFR2 inhibitor;(E)-2-CYANO-3-(4-HYDROXY-3;AG-1498;TYRPHOSTIN SU 1498;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE
- CBNumber
- CB12514856
- Molecular Formula
- C25H30N2O2
- Formula Weight
- 390.52
- MOL File
- 168835-82-3.mol
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Property
- Melting point:
- 126 °C
- Boiling point:
- 590.6±50.0 °C(Predicted)
- Density
- 1.100±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO.
- form
- powder
- pka
- 10.30±0.36(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- 1S/C25H30N2O2/c1-17(2)22-14-20(15-23(18(3)4)24(22)28)13-21(16-26)25(29)27-12-8-11-19-9-6-5-7-10-19/h5-7,9-10,13-15,17-18,28H,8,11-12H2,1-4H3,(H,27,29)/b21-13+
- InChIKey
- JANPYFTYAGTSIN-FYJGNVAPSA-N
- SMILES
- N(CCCc2ccccc2)C(=O)\C(=C\c1cc(c(c(c1)C(C)C)O)C(C)C)\C#N
- CAS DataBase Reference
- 168835-82-3
Safety
- WGK Germany
- WGK 3
- HS Code
- 2926.90.4801
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1193
- Product name
- SU1498
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $144
- Updated
- 2026/03/19
- Product number
- SML1193
- Product name
- SU1498
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $574
- Updated
- 2026/03/19
- Product number
- U0103
- Product name
- SU 1498
- Packaging
- 5MG
- Price
- $58
- Updated
- 2026/03/19
- Product number
- U0103
- Product name
- SU 1498
- Packaging
- 25MG
- Price
- $207
- Updated
- 2026/03/19
- Product number
- 16354
- Product name
- SU 1498
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $34
- Updated
- 2024/03/01
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Chemical Properties,Usage,Production
Description
SU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable.
Uses
SU 1498 is an inhibitor of VEGF receptor kinase.
Definition
ChEBI: SU1498 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine. It has a role as a vascular endothelial growth factor receptor antagonist. It is an enamide, a member of phenols, a nitrile, a monocarboxylic acid amide and a secondary carboxamide.
Biochem/physiol Actions
SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.
IC 50
Flk-1: 700 nM (IC50)
References
[1] SU JIN CHO. Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor.[J]. American Journal of Respiratory Cell and Molecular Biology, 2005, 33 6: 622-628. DOI:10.1165/rcmb.2005-0050oc
[2] YINGXIAO WANG. Interplay between integrins and FLK-1 in shear stress-induced signaling.[J]. American journal of physiology. Cell physiology, 2002, 283 5: C1540-7. DOI:10.1152/ajpcell.00222.2002
[3] L M STRAWN. Flk-1 as a target for tumor growth inhibition.[J]. Cancer research, 1996, 56 15: 3540-3545.
(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Preparation Products And Raw materials
Raw materials
Preparation Products
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