WAY-607500

Product Name: WAY-607500
CAS No.: 186610-88-8
Chemical Name: WAY-607500
Synonyms: SU 4981;WAY-607500;SU 4981, 10 mM in DMSO;3-(4-Morpholinobenzylidene)indolin-2-one;2H-Indol-2-one, 1,3-dihydro-3-[[4-(4-morpholinyl)phenyl]methylene]-
CBNumber: CB911669190
Molecular Formula: C19H18N2O2
Formula Weight: 306.37
MOL File: 186610-88-8.mol

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WAY-607500 Property

Boiling point:: 574.7±50.0 °C(Predicted)
Density: 1.265±0.06 g/cm3(Predicted)
pka: 12.93±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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WAY-607500 Chemical Properties,Usage,Production

Uses

hVEGF-IN-2 (compound 19) is a selective VEGF (Flk-1) receptor tyrosine kinases (RTK) inhibitor with an IC50 value of 2.5 μM. hVEGF-IN-2 inhibits PDGF RTK activity with an IC50 value of 33.1 μM. hVEGF-IN-2 can be used for the development of RTK-specific agents[1].

IC 50

VEGFR1: 2.5 μM (IC₅₀); PDGF: 33.1 μM (IC₅₀)

References

[1] Sun L, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. DOI:10.1021/jm980123i

WAY-607500 Preparation Products And Raw materials

Raw materials

Preparation Products

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WAY-607500 Suppliers

China 15 United States 2 Global 17

Shanghai YuanYe Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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ShangHai ChuanQian Chemcial Technique Centre

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Jinan Jiuli Biotechnology Co. , Ltd.

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Bide Pharmatech Ltd.

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TargetMol Chemicals Inc.

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186610-88-8, WAY-607500Related Search:

su5204 SU 5214 SU14813 CIVENTICHEM CV-409 SU5402 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide SU 4312

WAY-607500

3-(4-Morpholinobenzylidene)indolin-2-one

SU 4981

2H-Indol-2-one, 1,3-dihydro-3-[[4-(4-morpholinyl)phenyl]methylene]-

SU 4981, 10 mM in DMSO

186610-88-8