(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide

Product Name: (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
CAS No.: 168835-82-3
Chemical Name: (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide
Synonyms: CS-1481;CHEMBL261508;SU1498, >98%;Tyrphostin SU 1498, >98%;(E)-2-CYANO-3-(4-HYDROXY-3;AG-1498;TYRPHOSTIN SU 1498;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide;2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-
CBNumber: CB12514856
Molecular Formula: C25H30N2O2
Formula Weight: 390.52
MOL File: 168835-82-3.mol

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(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Property

Melting point:: 126 °C
Boiling point:: 590.6±50.0 °C(Predicted)
Density: 1.100±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO.
form: powder
pka: 10.30±0.36(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference: 168835-82-3

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Safety

HS Code: 2926.90.4801

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1193
Product name: SU1498
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1193
Product name: SU1498
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $520
Updated: 2024/03/01

TCI Chemical

Product number: U0103
Product name: SU 1498
Packaging: 5MG
Price: $87
Updated: 2024/03/01

TCI Chemical

Product number: U0103
Product name: SU 1498
Packaging: 25MG
Price: $310
Updated: 2024/03/01

Cayman Chemical

Product number: 16354
Product name: SU 1498
Purity: ≥98%
Packaging: 500μg
Price: $34
Updated: 2024/03/01

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(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Chemical Properties,Usage,Production

Description

SU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable.

Uses

SU 1498 is an inhibitor of VEGF receptor kinase.

Definition

ChEBI: SU1498 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enoic acid with the amino group of 3-phenylpropylamine. It has a role as a vascular endothelial growth factor receptor antagonist. It is an enamide, a member of phenols, a nitrile, a monocarboxylic acid amide and a secondary carboxamide.

Biochem/physiol Actions

SU1498 is a potent and selective inhibitor of the VEGFR2 receptor kinase, Flk-1 with an IC50 value of 700 nM. SU1498 is a very weak inhibitor of PDGFR-kinase, EGFR-kinase and HER-2 kinase with IC50 values > 50 μM. SU1498 has been used to study the role of VEGFR2 (Flk-1) in a variety of biological activities including angiogenesis, tumor growth inhibition, and stem cell proliferation.

References

1) Cho et al. (2005), Retinoic acid and erythropoietin maintain alveolar development in mice treated with an angiogenesis inhibitor; Am. J. Respir. Cell Mol. Biol., 33 622 2) Wang et al. (2002), Interplay between integrins and FLK-1 in shear stress-induced signaling; Am. J. Physiol. Cell Physiol., 283 C1540 3) Strawn et al. (1996), FLK-1 as a target for tumor growth inhibition; Cancer Res., 56 3540

(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide Suppliers

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168835-82-3, (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamideRelated Search:

WAY-607500 su5204 SU14813 CIVENTICHEM CV-409 SU5402 Bortezomib Sunitinib Malate Apigenin NVP-BEZ 235 SU 5214 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE SUN11602 SU 4942 SU 11274 SU 5205 SU 4312 CHOLESTEROL ESTERASE Ethylamine

(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide

(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy

SU1498, >98%

Tyrphostin SU 1498, >98%

CS-1481

(E)-2-CYANO-3-(4-HYDROXY-3

5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE

CHEMBL261508

SU1498; TYRPHOSTIN SU 1498; CHEMBL261508; (E)-2-CYANO-3-(4-HYDROXY-3;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE

AG-1498;TYRPHOSTIN SU 1498

2-Propenamide, 2-cyano-3-[4-hydroxy-3,5-bis(1-methylethyl)phenyl]-N-(3-phenylpropyl)-, (2E)-

Vascular endothelial growth factor receptor,Inhibitor,Su-1498,AG1498,AG-1498,Su1498,Tyrphostin SU1498,inhibit,Tyrphostin SU-1498,VEGFR,SU 1498

168835-82-3