ChemicalBook > CAS DataBase List > SU 5205

SU 5205

Product Name: SU 5205
CAS No.: 3476-86-6
Chemical Name: SU 5205
Synonyms: SU 5205;SU5205, 10 mM in DMSO;SU 5205; SU-5205; SU5205;(z)-3-(4-fluorobenzylidene)indolin-2-one;2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-;mitogenesis,Inhibitor,VEGFR2,Vascular endothelial growth factor receptor,FLK-1,SU-5205,endothelial,VEGFR,SU5205,inhibit
CBNumber: CB13123194
Molecular Formula: C15H10FNO
Formula Weight: 239.24
MOL File: 3476-86-6.mol

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SU 5205 Property

Melting point:: 194-196 °C
Boiling point:: 435.3±45.0 °C(Predicted)
Density: 1.306±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
pka: 12.69±0.20(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27310
Product name: SU 5205
Packaging: 100mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 27310
Product name: SU 5205
Packaging: 250mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 27310
Product name: SU 5205
Packaging: 50mg
Price: $63
Updated: 2024/03/01

Arctom

Product number: AS553614
Product name: Su5205
Purity: 97%
Packaging: 5mg
Price: $28
Updated: 2021/12/16

Arctom

Product number: AS553614
Product name: Su5205
Purity: 97%
Packaging: 10mg
Price: $37
Updated: 2021/12/16

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SU 5205 Chemical Properties,Usage,Production

Uses

SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].

Biological Activity

SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM.

Synthesis

59-48-3

459-57-4

3476-86-6

GENERAL STEPS: 2-Indolone (1 eq.) and p-fluorobenzaldehyde (1 eq.) were added to ethanol (EtOH, 3 mL/0.2 mmol) and the mixture was stirred until completely dissolved. Subsequently piperidine (0.1 eq.) was added and the reaction mixture was heated to 90 °C and kept reacting for 3-7 hours. After completion of the reaction, it was cooled to room temperature. The resulting precipitate was collected by filtration, washed with cold ethanol and dried to give 3-(4-fluorophenylmethylene)indolin-2-one crude. If further purity is required, the product can be purified by ethanol recrystallization.

in vitro

SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC ₅₀ of 5.1 μM.

target

Target	Value
VEGFR2 (Cell-free assay)	9.6 μM

IC 50

Flk-1: 9.6 μM (IC₅₀)

References

[1] Huh S, et al. Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biol Pharm Bull. 2010;33(7):1242-5. DOI:10.1248/bpb.33.1242
[2] Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.

SU 5205 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SU 5205 manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: SU 5205 3476-86-6
Price: US $9.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-01

3476-86-6, SU 5205Related Search:

SU 5416 SU4312 SU 9516 su5204 SU5208 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE VEGFR2 Kinase Inhibitor I IC 261 NSC 247030 SU 5214 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE SUN11602 SU 4942 SU 11274 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide SU 4312

SU 5205

2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro-

SU 5205; SU-5205; SU5205

mitogenesis,Inhibitor,VEGFR2,Vascular endothelial growth factor receptor,FLK-1,SU-5205,endothelial,VEGFR,SU5205,inhibit

SU5205, 10 mM in DMSO

(z)-3-(4-fluorobenzylidene)indolin-2-one

3476-86-6