ChemicalBook > CAS DataBase List > SU 11274

SU 11274

Product Name
SU 11274
CAS No.
658084-23-2
Chemical Name
SU 11274
Synonyms
1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-;Sul1274;PKI-SU11274;SU 11274, >=98%;SU 11274，SU 11274;SU 11274 USP/EP/BP;Met Kinase Inhibitor;SU11274(PKI-SU11274);SU-11274;PKI-SU11274;SU 11274;Met Kinase Inhibitor SU11274 SU-11274
CBNumber
CB3504776
Molecular Formula
C28H30ClN5O4S
Formula Weight
568.09
MOL File
658084-23-2.mol
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SU 11274 Property

Density 
1.401±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 10 mg/mL at 60 °C
pka
11.62±0.20(Predicted)
form 
powder
color 
orange
InChIKey
FPYJSJDOHRDAMT-KQWNVCNZSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
448101
Product name
Met Kinase Inhibitor
Packaging
1mg
Price
$154
Updated
2023/06/20
Cayman Chemical
Product number
14861
Product name
SU 11274
Purity
≥95%
Packaging
500μg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
14861
Product name
SU 11274
Purity
≥95%
Packaging
1mg
Price
$84
Updated
2024/03/01
Sigma-Aldrich
Product number
S9820
Product name
SU 11274
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$921
Updated
2022/05/15
Cayman Chemical
Product number
14861
Product name
SU 11274
Purity
≥95%
Packaging
5mg
Price
$130
Updated
2024/03/01
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SU 11274 Chemical Properties,Usage,Production

Description

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.

Uses

SU 11274 is a competitive inhibitor of Met kinase activity.

Definition

ChEBI: 1h-indole-5-sulfonamide, n-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1h-pyrrol-2-yl]methylene]-2,3-dihydro-n-methyl-2-oxo-, (3z)- is a sulfonamide.

Biochem/physiol Actions

SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2

References

[1] wang x1, le p, liang c, chan j, kiewlich d, miller t, harris d, sun l, rice a, vasile s, blake ra, howlett ar, patel n, mcmahon g, lipson ke. potent and selective inhibitors of the met [hepatocyte growth factor/scatter factor (hgf/sf) receptor] tyrosine kinase block hgf/sf-induced tumor cell growth and invasion. mol cancer ther. 2003 nov;2(11):1085-92.
[2] leiser d1, pochon b1, blank-liss w1, francica p1, glück aa1, aebersold dm1, zimmer y1, medová m2. targeting of the met receptor tyrosine kinase by small molecule inhibitors leads to met accumulation by impairing the receptor downregulation. febs lett. 2014 mar 3;588(5):653-8.

SU 11274 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SU 11274 manufacturers

Career Henan Chemical Co
Product
(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide 658084-23-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide 658084-23-2
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

658084-23-2, SU 11274Related Search:

SUN11602 SU 4942 SU 5205 (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide SU 4312 FORMANILIDE Acetanilide 5-CHLORO-3-[(3,5-DIMETHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE SU5402 N-Desethyl Sunitinib PHA-665752 1,9-Pyrazoloanthrone Dasatinib Crizotinib Olaparib BEZ235 (NVP-BEZ235, Dactolisib) 3-(4-ISOPROPYLBENZYLIDENYL)INDOLIN-2-ONE SU 5214

  • (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
  • (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
  • Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem
  • SU-11274;PKI-SU11274;SU 11274
  • PKI-SU11274
  • N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
  • N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide SU11274
  • SU 11274, >=98%
  • Met Kinase Inhibitor
  • (Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methy
  • (3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide
  • SU 11274，SU 11274
  • (Z)-N-(3-chlorophenyl)-3-((3,5-diMethyl-4-(4-Methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)Methylene)-N-Methyl-2-oxoindoline-5-sulfonaMide
  • SU11274(PKI-SU11274)
  • Sul1274
  • (Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(1-methylpiperazine-4-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide
  • 1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-
  • SU 11274 USP/EP/BP
  • Met Kinase Inhibitor SU11274 SU-11274
  • SU 11274,Inhibitor,Autophagy,inhibit,c-Met/HGFR,Apoptosis,SU-11274,SU11274
  • 658084-23-2
  • C28H30ClN5O4S
  • C28H30CIN5O4S
  • C28Cl1H30N5O4S1
  • Inhibitors