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Toceranib Phosphate

Product Name
Toceranib Phosphate
CAS No.
874819-74-6
Chemical Name
Toceranib Phosphate
Synonyms
PHA 291639E;SU11654 phosphate;PHA 291639 phosphate;Toceranib (phosphate);PHA 291639E (phosphate);Toceranib phosphate(SU 11654);Toceranib (PHA 291639) phosphate;5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide;(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate;5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
CBNumber
CB42563239
Molecular Formula
C22H28FN4O6P
Formula Weight
494.46
MOL File
874819-74-6.mol
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Toceranib Phosphate Property

Melting point:
>270°C (dec.)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly, Heated)
form 
Solid
color 
Yellow to Dark Orange
InChI
InChI=1S/C22H25FN4O2.H3O4P/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27;1-5(2,3)4/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28);(H3,1,2,3,4)/b17-12-;
InChIKey
AOORBROPMMRREB-HBPAQXCTSA-N
SMILES
P(O)(O)(O)=O.C(/C1NC(C)=C(C(=O)NCCN2CCCC2)C=1C)=C1/C(NC2=CC=C(F)C=C/12)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T525503
Product name
ToceranibPhosphate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
T525503
Product name
ToceranibPhosphate
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
BT162330
Product name
Toceranib phosphate
Packaging
5mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-1231
Product name
Toceranibphosphate
Packaging
10mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
BT162330
Product name
Toceranib phosphate
Packaging
10mg
Price
$80
Updated
2021/12/16
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Toceranib Phosphate Chemical Properties,Usage,Production

Description

Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect.

Uses

Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.

Side effects

Common side effects of Toceranib Phosphate may include diarrhoea, decreased or lack of appetite, claudication or weight loss. Less common side effects include muscle pain, low white blood cell count, low blood protein levels, blood clots (which may appear as swelling in the legs or difficulty breathing), pancreatitis, loss of nose colour, changes in skin hair, nosebleeds, seizures, high blood pressure and itching. Serious side effects include prolonged loss of appetite, severe diarrhoea or bloody stools, bruising or bleeding. In cats, gastrointestinal effects, low blood counts, liver and kidney problems, and hair loss have been reported.

target

KIT

Toceranib Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Toceranib Phosphate Suppliers

Krain Pharmaceutical Technology CO.,Ltd
Tel
18252089365
Email
Krain_kerun@163.com
Country
China
ProdList
2618
Advantage
58
Shanghai Mokai Pharmaceutical Technology Co., Ltd.
Tel
021-60951261 18601606476
Email
nancy@mkpharma.cn
Country
China
ProdList
453
Advantage
58
Shanghai Hope Chem Co., Ltd.,
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
482
Advantage
55
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19173
Advantage
64
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Suzhou Pharmaceutical Technology co.,ltd
Tel
0510-88771160 18051901298
Fax
0510-8877116
Email
2013446823@qq.com
Country
China
ProdList
52
Advantage
61
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
Beri Pharma Co., Ltd.
Tel
0756-07568699456 13427714006
Fax
+86-756-8699456
Email
sales@zhberi.com
Country
China
ProdList
189
Advantage
58
Nanjing River Chemical Co., Ltd.
Tel
13951936332 18305166317
Fax
-
Email
info@serpharm.com
Country
China
ProdList
493
Advantage
55
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View Lastest Price from Toceranib Phosphate manufacturers

S&Y Biochem Co.,Ltd
Product
Toceranib Phosphate 874819-74-6
Price
US $1.00/kg
Min. Order
0.1kg
Purity
99
Supply Ability
100
Release date
2024-08-01
Hpets Biotech Company (Chongqing) Co.,ltd
Product
Toceranib phosphate 874819-74-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 tons
Release date
2023-03-21
Henan Aochuang Chemical Co.,Ltd.
Product
Toceranib Phosphate 874819-74-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

874819-74-6, Toceranib PhosphateRelated Search:


  • 1H-Pyrrole-3-carboxaMide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]-, phosphate (1:1)
  • 5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide phosphate
  • PHA 291639E
  • Toceranib (phosphate)
  • Toceranib (PHA 291639) phosphate
  • Toceranib phosphate(SU 11654)
  • 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide,phosphoric acid
  • SU11654 phosphate
  • PHA 291639 phosphate
  • (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate
  • PHA 291639E (phosphate)
  • 1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-, phosphate (1:1) (9CI, ACI)
  • 5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
  • 5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
  • 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-Pyrrole-3-carboxamide phosphate (1:1) (9CI ACI)
  • 5-(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-N-2-(pyrrolidin-1-yl)ethyl-1H-pyrrol-3-carboxamide phosphate (1:1)
  • 874819-74-6
  • C22H25FN4O2H3PO4
  • C22H25FN4O2H3O4P
  • API