Toceranib Phosphate
- Product Name
- Toceranib Phosphate
- CAS No.
- 874819-74-6
- Chemical Name
- Toceranib Phosphate
- Synonyms
- PHA 291639E;SU11654 phosphate;PHA 291639 phosphate;Toceranib (phosphate);PHA 291639E (phosphate);Toceranib phosphate(SU 11654);Toceranib (PHA 291639) phosphate;5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide;(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate;5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
- CBNumber
- CB42563239
- Molecular Formula
- C22H28FN4O6P
- Formula Weight
- 494.46
- MOL File
- 874819-74-6.mol
Toceranib Phosphate Property
- Melting point:
- >270°C (dec.)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly, Heated)
- form
- Solid
- color
- Yellow to Dark Orange
- InChI
- InChI=1S/C22H25FN4O2.H3O4P/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27;1-5(2,3)4/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28);(H3,1,2,3,4)/b17-12-;
- InChIKey
- AOORBROPMMRREB-HBPAQXCTSA-N
- SMILES
- P(O)(O)(O)=O.C(/C1NC(C)=C(C(=O)NCCN2CCCC2)C=1C)=C1/C(NC2=CC=C(F)C=C/12)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T525503
- Product name
- ToceranibPhosphate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T525503
- Product name
- ToceranibPhosphate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BT162330
- Product name
- Toceranib phosphate
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-1231
- Product name
- Toceranibphosphate
- Packaging
- 10mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 6555BB
- Product name
- Toceranibphosphate
- Packaging
- 10mg
- Price
- $120
- Updated
- 2021/12/16
Toceranib Phosphate Chemical Properties,Usage,Production
Description
Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect.
Uses
Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.
Side effects
Common side effects of Toceranib Phosphate may include diarrhoea, decreased or lack of appetite, claudication or weight loss. Less common side effects include muscle pain, low white blood cell count, low blood protein levels, blood clots (which may appear as swelling in the legs or difficulty breathing), pancreatitis, loss of nose colour, changes in skin hair, nosebleeds, seizures, high blood pressure and itching. Serious side effects include prolonged loss of appetite, severe diarrhoea or bloody stools, bruising or bleeding. In cats, gastrointestinal effects, low blood counts, liver and kidney problems, and hair loss have been reported.
target
KIT
Toceranib Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Toceranib Phosphate Suppliers
- Tel
- 18252089365
- Krain_kerun@163.com
- Country
- China
- ProdList
- 2619
- Advantage
- 58
- Tel
- 021-60951261 18601606476
- nancy@mkpharma.cn
- Country
- China
- ProdList
- 453
- Advantage
- 58
- Tel
- +21-18501659228 18501659228
- Fax
- sales@hope-chem.com
- info@hope-chem.com
- Country
- China
- ProdList
- 479
- Advantage
- 55
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 19179
- Advantage
- 64
- Tel
- 025-58196018 800028039
- Fax
- 025-83453306
- sales@fartop.net
- Country
- China
- ProdList
- 2229
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 0510-88771160 18051901298
- Fax
- 0510-8877116
- 2013446823@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 61
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 0756-07568699456 13427714006
- Fax
- +86-756-8699456
- sales@zhberi.com
- Country
- China
- ProdList
- 189
- Advantage
- 58
- Tel
- 13951936332 18305166317
- Fax
- -
- info@serpharm.com
- Country
- China
- ProdList
- 493
- Advantage
- 55
View Lastest Price from Toceranib Phosphate manufacturers
- Product
- Toceranib Phosphate 874819-74-6
- Price
- US $1.00/kg
- Min. Order
- 0.1kg
- Purity
- 99
- Supply Ability
- 100
- Release date
- 2024-08-01
- Product
- Toceranib phosphate 874819-74-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-03-21
- Product
- Toceranib Phosphate 874819-74-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26