Toceranib Phosphate

ChemicalBook > CAS DataBase List > Toceranib Phosphate

Product Name: Toceranib Phosphate
CAS No.: 874819-74-6
Chemical Name: Toceranib Phosphate
Synonyms: PHA 291639E;SU11654 phosphate;PHA 291639 phosphate;Toceranib (phosphate);PHA 291639E (phosphate);Toceranib phosphate(SU 11654);Toceranib (PHA 291639) phosphate;5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide;(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate;5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
CBNumber: CB42563239
Molecular Formula: C22H28FN4O6P
Formula Weight: 494.46
MOL File: 874819-74-6.mol

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Toceranib Phosphate Property

Melting point:: >270°C (dec.)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly, Heated)
form: Solid
color: Yellow to Dark Orange
InChI: InChI=1S/C22H25FN4O2.H3O4P/c1-13-19(12-17-16-11-15(23)5-6-18(16)26-21(17)28)25-14(2)20(13)22(29)24-7-10-27-8-3-4-9-27;1-5(2,3)4/h5-6,11-12,25H,3-4,7-10H2,1-2H3,(H,24,29)(H,26,28);(H3,1,2,3,4)/b17-12-;
InChIKey: AOORBROPMMRREB-HBPAQXCTSA-N
SMILES: P(O)(O)(O)=O.C(/C1NC(C)=C(C(=O)NCCN2CCCC2)C=1C)=C1/C(NC2=CC=C(F)C=C/12)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T525503
Product name: ToceranibPhosphate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: T525503
Product name: ToceranibPhosphate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BT162330
Product name: Toceranib phosphate
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-1231
Product name: Toceranibphosphate
Packaging: 10mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 6555BB
Product name: Toceranibphosphate
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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Toceranib Phosphate Chemical Properties,Usage,Production

Description

Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect.

Uses

Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.

Side effects

Common side effects of Toceranib Phosphate may include diarrhoea, decreased or lack of appetite, claudication or weight loss. Less common side effects include muscle pain, low white blood cell count, low blood protein levels, blood clots (which may appear as swelling in the legs or difficulty breathing), pancreatitis, loss of nose colour, changes in skin hair, nosebleeds, seizures, high blood pressure and itching. Serious side effects include prolonged loss of appetite, severe diarrhoea or bloody stools, bruising or bleeding. In cats, gastrointestinal effects, low blood counts, liver and kidney problems, and hair loss have been reported.

target

KIT

Toceranib Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Toceranib Phosphate manufacturers

S&Y Biochem Co.,Ltd

Product: Toceranib Phosphate 874819-74-6
Price: US $1.00/kg
Min. Order: 0.1kg
Purity: 99
Supply Ability: 100
Release date: 2024-08-01

Hpets Biotech Company (Chongqing) Co.,ltd

Product: Toceranib phosphate 874819-74-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2023-03-21

Henan Aochuang Chemical Co.,Ltd.

Product: Toceranib Phosphate 874819-74-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

874819-74-6, Toceranib PhosphateRelated Search:

Persulfate Compound phosphate Toceranib Toceranib Phosphate

1H-Pyrrole-3-carboxaMide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]-, phosphate (1:1)

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide phosphate

PHA 291639E

Toceranib (phosphate)

Toceranib (PHA 291639) phosphate

Toceranib phosphate(SU 11654)

5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide,phosphoric acid

SU11654 phosphate

PHA 291639 phosphate

(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate

PHA 291639E (phosphate)

1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-, phosphate (1:1) (9CI, ACI)

5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide

5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide

5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-Pyrrole-3-carboxamide phosphate (1:1) (9CI ACI)

5-(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-N-2-(pyrrolidin-1-yl)ethyl-1H-pyrrol-3-carboxamide phosphate (1:1)

874819-74-6

C22H25FN4O2H3PO4

C22H25FN4O2H3O4P

API