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SC 66

Product Name
SC 66
CAS No.
871361-88-5
Chemical Name
SC 66
Synonyms
SC 66;CS-2480;SC66;SC 66;2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA;(2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone;(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone;Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-;Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
CBNumber
CB42565930
Molecular Formula
C18H16N2O
Formula Weight
276.33
MOL File
871361-88-5.mol
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SC 66 Property

storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥5mg/mL (warmed)
form 
powder
color 
faint yellow to dark yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10876
Product name
SC-66
Purity
≥98%
Packaging
5mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
10876
Product name
SC-66
Purity
≥98%
Packaging
10mg
Price
$71
Updated
2024/03/01
Cayman Chemical
Product number
10876
Product name
SC-66
Purity
≥98%
Packaging
25mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
10876
Product name
SC-66
Purity
≥98%
Packaging
100mg
Price
$510
Updated
2024/03/01
Tocris
Product number
4398
Product name
SC66
Purity
≥98%(HPLC)
Packaging
50
Price
$378
Updated
2021/12/16
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SC 66 Chemical Properties,Usage,Production

Description

Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth.

Uses

SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance.

storage

-20°C

SC 66 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC 66 Suppliers

China 77 India 1 United Kingdom 1 United States 15 Global 94
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from SC 66 manufacturers

Career Henan Chemical Co
Product
SC 66 871361-88-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

871361-88-5, SC 66Related Search:

4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC-514 SC 57461A α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

  • SC 66
  • Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)-
  • (2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
  • CS-2480
  • SC66;SC 66
  • (2E,6E)-2,6-Bis(pyridin-4-ylmethylene)cyclohexanone
  • Akt,SC 66,PKB,Protein kinase B,SC-66,SC66,Inhibitor,inhibit,Apoptosis
  • 2E,?6E-?BIS(4-?PYRIDINYLMETHYLENE)-?CYCLOHEXA
  • 871361-88-5