SC-514

Product Name: SC-514
CAS No.: 354812-17-2
Chemical Name: SC-514
Synonyms: SC-514;CS-707;GK01140;GK-01140;GK 01140;SC-514, >=98%;SC-514;GK 01140;SC-514 USP/EP/BP;IKK-2 Inhibitor, SC-514;4-Amino-[2,3']bithiophenyl-5-carboxamide
CBNumber: CB7832024
Molecular Formula: C9H8N2OS2
Formula Weight: 224.3
MOL File: 354812-17-2.mol

More

Less

SC-514 Property

Melting point:: 209-211°C
Boiling point:: 399.2±42.0 °C(Predicted)
Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 15.63±0.50(Predicted)
form: powder
color: white to light brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0557
Product name: SC-514
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $93.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 401479
Product name: IKK-2 Inhibitor, SC-514
Packaging: 1mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 10010267
Product name: SC-514
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10010267
Product name: SC-514
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0557
Product name: SC-514
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $289
Updated: 2024/03/01

More

Less

SC-514 Chemical Properties,Usage,Production

Description

SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1

Chemical Properties

Yellow Solid

Uses

A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.

Definition

ChEBI: 3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide is a ring assembly and a member of thiophenes.

storage

Store at +4°C

References

1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861

SC-514 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SC-514 Suppliers

Canada 1 China 82 India 2 United Kingdom 3 United States 22 Global 110

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4668
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 496
Advantage: 55

354812-17-2, SC-514Related Search:

TG003 APICIDIN Doxorubicin hydrochloride (+)-Camptothecin 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 2-AMino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester SC 57461A SC 66 α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile BAY 11-7082 MG-132 IKK Inhibitor III, BMS-345541 Ibrutinib 3-AMINOTHIOPHENE-2-CARBOXAMIDE

SC-514, >=98%

3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide

SC-514;GK 01140

IKK-2 Inhibitor, SC-514

4-Amino-[2',3'-bithiophene]-5-carboxamide

SC-514

5-(Thien-3-yl)-3-aminothiophene-2-carboxamide

GK 01140

GK01140

GK-01140

4-Amino-[2,3']bithiophenyl-5-carboxamide

[2,3'-Bithiophene]-5-carboxamide, 4-amino-

4-Amino-[2,3']bithiophenyl-5-carboxamide GK 01140

4-Amino-[2,3"]bithiophenyl-5-carboxylic acid amide

IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

GK 01140; SC 514; SC514; GK-01140; GK01140

CS-707

SC-514 USP/EP/BP

IKK,I kappa B kinase,GK-01140,SC-514,GK01140,IκB kinase,Inhibitor,SC514,SC 514,inhibit

4-Amino-[2,3'-bithiophene]-5-carboxamide

354812-17-2

NF-kB

IκB/IKK

Apis

All Inhibitors

Inhibitors