IKK Inhibitor III, BMS-345541
- Product Name
- IKK Inhibitor III, BMS-345541
- CAS No.
- 445430-58-0
- Chemical Name
- IKK Inhibitor III, BMS-345541
- Synonyms
- CS-1910;BMS345541 (free base);BMS-345541 (free base);BMS 345541 (free base);IKK Inhibitor III, BMS-345541;BMS345541;BMS 345541;IKK INHIBITOR III;IKK Inhibitor III, BMS-345541 USP/EP/BP;BMS-345541 free base (BMS345541 (free base);N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine;N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine
- CBNumber
- CB12618570
- Molecular Formula
- C14H17N5
- Formula Weight
- 255.32
- MOL File
- 445430-58-0.mol
IKK Inhibitor III, BMS-345541 Property
- Boiling point:
- 449.5±45.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- insoluble in H2O; ≥70 mg/mL in DMSO; ≥2.49 mg/mL in EtOH with gentle warming and ultrasonic
- form
- Powder
- pka
- 9.02±0.10(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 445430-58-0
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 401480
- Product name
- IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem
- Purity
- IKK Inhibitor III, BMS-345541, CAS 445430-58-0, is a cell-permeable, potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC?? = ~ 300 nM).
- Packaging
- 1MG
- Price
- $294
- Updated
- 2023/06/20
- Product number
- B596080
- Product name
- BMS-345541
- Packaging
- 25mg
- Price
- $495
- Updated
- 2021/12/16
- Product number
- CS-1238
- Product name
- BMS-345541
- Purity
- 99.57%
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- B4655
- Product name
- BMS-345541(freebase)
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- B4655
- Product name
- BMS-345541(freebase)
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
IKK Inhibitor III, BMS-345541 Chemical Properties,Usage,Production
Characteristics
Allosteric IKK inhibitors have anti-inflammatory activity.
Uses
BMS-345541 is a potent, selective, and allosteric site-binding inhibitor of IKK β (IKK-2) and shows 10 times greater selectivity over IKK α (IKK-1). BMS-345541 also inhibits cellular Iκβα phosphorylation and has some anti-inflammatory properties.
Definition
ChEBI: N'-(1,8-dimethyl-4-imidazo[1,2-a]quinoxalinyl)ethane-1,2-diamine is a quinoxaline derivative.
Biological Activity
BMS-345541 highly selectively inhibits the catalytic subunits of IKK-2 and IKK-1 with IC50s of 0.3 μM and 4 μM, respectively.
in vitro
BMS-34554 (5 μM) induces time-dependent dephosphorylation of IκBα and p65. Treatment of T-ALL cells with BMS-34554 resulted in nuclear translocation of FOXO3a, including control of the expression level of the p21CIP1 gene. In human umbilical vein endothelial cells, BMS-345541 inhibits TNFα-induced expression of ICAM-1 and VCAM-1 with IC50 of 5 μM.
in vivo
BMS-345541 (100 mg/kg) reduced the cumulative arthritis damage score from 4.4 to 0, along with low-grade degradation and inflammation of the tibiotarsal joint, synovial hyperplasia, bone resorption, and severity of cartilage erosion. There was no apparent damage to the joints of the animals, which was indistinguishable from the histological phenotype observed in those from age-matched, disease-free control animals. BMS-345541 dose-dependently inhibited IL-1β signaling, with animals in the 100 mg/kg dose group exhibiting levels consistent with disease-free control animals.
target
| Target | Value |
| IKK2 (Cell-free assay) | 0.3 μM |
| IKK1 (Cell-free assay) | 4 μM |
IKK Inhibitor III, BMS-345541 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from IKK Inhibitor III, BMS-345541 manufacturers
- Product
- BMS-345541 445430-58-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 500kg/month
- Release date
- 2019-08-01