BMS 193885
- Product Name
- BMS 193885
- CAS No.
- 679839-66-8
- Chemical Name
- BMS 193885
- Synonyms
- BMS-193885 salt
- CBNumber
- CB44806426
- Molecular Formula
- C36H48N4O9
- Formula Weight
- 680.8
- MOL File
- 679839-66-8.mol
BMS 193885 Property
- Melting point:
- 125-126 °C(Solv: acetonitrile (75-05-8))
- storage temp.
- Desiccate at RT
- solubility
- <68.08mg/ml in DMSO; <13.62mg/ml in H2O
- form
- solid
- color
- Pale yellow
N-Bromosuccinimide Price
- Product number
- B695575
- Product name
- BMS193885
- Packaging
- 2.5mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- B7327
- Product name
- BMS193885
- Packaging
- 10mg
- Price
- $402
- Updated
- 2021/12/16
BMS 193885 Chemical Properties,Usage,Production
Uses
BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition[1].
Biological Activity
bms-193885 is a potent and selective neuropeptide y1 receptor antagonist with ic50 of 5.9nm.neuropeptide y receptor 1 is g-protein coupled receptors and implicated in the modulation of food intake and energy homeostasis. neuropeptide y1 is expressed in many tissues including the hippocampus, hypothalamus, amygdala and the cortex of the brain as well as in peripheral tissues heart, kidney, skeletal muscle. the localization and expression suggests their involvement in the regulation of food intake and body weight.in cellular culture, bms-193885 displayed functional antagonism of neuropeptide y1 in aforskolin-stimulated c-amp production assay using cho cells expressing the human y(1) receptor 1.
in vivo
administration of bms-193885 at a dosage of 10mg/kg leads to 1h neuropeptide y-induced food intake in rat and the spontaneous overnight food consumpetion 2 . chronic administration of bms-193885 (10 mg/kg) i.p. for 44 days significantly reduced food intake and the rate of body weight gain as compared to their control without developing tolerance or affecting water intake 2.
storage
Desiccate at RT
References
1. poindexter gs, bruce ma, leboulluec kl, et al. dihydropyridine neuropeptide y y(1) receptor antagonists. bioorganic & medicinal chemistry letters. 2002;12(3):379-382.2. antal-zimanyi i, bruce ma, leboulluec kl, et al. pharmacological characterization and appetite suppressive properties of bms-193885, a novel and selective neuropeptide y(1) receptor antagonist. european journal of pharmacology. 2008;590(1-3):224-232.
BMS 193885 Preparation Products And Raw materials
Raw materials
Preparation Products
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