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BMS 193885

Product Name
BMS 193885
CAS No.
679839-66-8
Chemical Name
BMS 193885
Synonyms
BMS-193885 salt
CBNumber
CB44806426
Molecular Formula
C36H48N4O9
Formula Weight
680.8
MOL File
679839-66-8.mol
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BMS 193885 Property

Melting point:
125-126 °C(Solv: acetonitrile (75-05-8))
storage temp. 
Desiccate at RT
solubility 
<68.08mg/ml in DMSO; <13.62mg/ml in H2O
form 
solid
color 
Pale yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B695575
Product name
BMS193885
Packaging
2.5mg
Price
$305
Updated
2021/12/16
ApexBio Technology
Product number
B7327
Product name
BMS193885
Packaging
10mg
Price
$402
Updated
2021/12/16
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BMS 193885 Chemical Properties,Usage,Production

Biological Activity

bms-193885 is a potent and selective neuropeptide y1 receptor antagonist with ic50 of 5.9nm.neuropeptide y receptor 1 is g-protein coupled receptors and implicated in the modulation of food intake and energy homeostasis. neuropeptide y1 is expressed in many tissues including the hippocampus, hypothalamus, amygdala and the cortex of the brain as well as in peripheral tissues heart, kidney, skeletal muscle. the localization and expression suggests their involvement in the regulation of food intake and body weight.in cellular culture, bms-193885 displayed functional antagonism of neuropeptide y1 in aforskolin-stimulated c-amp production assay using cho cells expressing the human y(1) receptor 1.

in vivo

administration of bms-193885 at a dosage of 10mg/kg leads to 1h neuropeptide y-induced food intake in rat and the spontaneous overnight food consumpetion 2 . chronic administration of bms-193885 (10 mg/kg) i.p. for 44 days significantly reduced food intake and the rate of body weight gain as compared to their control without developing tolerance or affecting water intake 2.

storage

Desiccate at RT

References

1. poindexter gs, bruce ma, leboulluec kl, et al. dihydropyridine neuropeptide y y(1) receptor antagonists. bioorganic & medicinal chemistry letters. 2002;12(3):379-382.2. antal-zimanyi i, bruce ma, leboulluec kl, et al. pharmacological characterization and appetite suppressive properties of bms-193885, a novel and selective neuropeptide y(1) receptor antagonist. european journal of pharmacology. 2008;590(1-3):224-232.

BMS 193885 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 193885 Suppliers

TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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19892
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Changzhou Furuisi Biotechnology Co., Ltd
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0519-85524369
Email
3477467573@qq.com
Country
China
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8618
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Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3063
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58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
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2490
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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+86-18521732826
Email
market@aladdin-e.com
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China
ProdList
48518
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58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
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58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3136
Advantage
58

679839-66-8, BMS 193885Related Search:


  • BMS-193885 salt
  • 679839-66-8