BMS 303141

Background

Product Name: BMS 303141
CAS No.: 943962-47-8
Chemical Name: BMS 303141
Synonyms: CS-887;BMS30314;BMS 303141;CAS:943962-47-8;BMS303141 ，S0277;BMS 303141, >=98%;BMS303141; BMS 303141;BMS-303141 >=98% (HPLC);BMS-303141, 10 mM in DMSO;3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide
CBNumber: CB32627606
Molecular Formula: C19H15Cl2NO4S
Formula Weight: 424.3
MOL File: 943962-47-8.mol

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BMS 303141 Property

Boiling point:: 591.5±60.0 °C(Predicted)
Density: 1.462±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 4.94±0.48(Predicted)
form: powder
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI: 1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3
InChIKey: SIIPNDKXZOTLEA-UHFFFAOYSA-N
SMILES: O=S(NC1=C(OC)C=CC(C2=CC=CC=C2)=C1)(C3=C(O)C(Cl)=CC(Cl)=C3)=O

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Chronic 4

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0784
Product name: BMS-303141
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $138
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML0784
Product name: BMS-303141
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $559
Updated: 2026/03/19

Cayman Chemical

Product number: 16239
Product name: BMS 303141
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 16239
Product name: BMS 303141
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 16239
Product name: BMS 303141
Purity: ≥98%
Packaging: 25mg
Price: $388
Updated: 2024/03/01

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BMS 303141 Chemical Properties,Usage,Production

Description

BMS-303141 (943963-47-8) is a potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells.1,2Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice.2A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia.2Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells.3Reduces cell cycle progression in iBN cells.4

Uses

BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.

Definition

ChEBI: 3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide is a member of biphenyls.

Biochem/physiol Actions

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.

storage

Store at -20°C

Background

The small-molecule BMS-303141 is a potent inhibitor of ATP-citrate lyase. ACL catalyzes the formation of cytosolic acetyl-CoA and oxaloacetate in the cytosol, which is the key step for fatty acid and cholesterol biosynthesis. BMS-303141 also weakly inhibits acetyl-CoA carboxylase isoforms ACC1 and ACC2. Treatment of high-fat fed mice with BMS-303141 reduced weight gain and decreased levels of plasma cholesterol, triglycerides, and glucose. BMS-303141 treatment of prostate cancer cells impaired cell proliferation or induced death in androgen-depleted, castration-resistant prostate cancer cells. Hepatocellular carcinoma cells responded to treatment with BMS-303141, reducing cell proliferation and promoting apoptosis. BMS-303141 is thought to induce endoplasmic reticulum stress and activate the p-eIF2α/ATF4/CHOP pathway to promote apoptosis. The combined treatment of a mouse xenograft model with BMS-303141 and a protein kinase inhibitor reduced tumor volume and weight.

References

[1] JAMES J. LI . 2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2007, 17 11: Pages 3208-3211. DOI:10.1016/j.bmcl.2007.03.017
[2] ZHENGPING MA Dong C Ching Hsuen Chu. A novel direct homogeneous assay for ATP citrate lyase.[J]. Journal of Lipid Research, 2009, 50 10: 2131-2135. DOI:10.1194/jlr.d900008-jlr200
[3] SUPRIYA SHAH. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.[J]. Oncotarget, 2016: 43713-43730. DOI:10.18632/oncotarget.9666
[4] JESS RHEE R D. Regulation of Lipid Metabolism and Cell Cycle Progression By PU.1 in Myeloid Progenitor Cells[J]. Blood, 2017, 130 1: 2433-2433. DOI:10.1182/blood.v130.suppl\_1.2433.2433

BMS 303141 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 303141 Suppliers

China 122 India 1 United Kingdom 1 United States 19 Global 143

Shanghai Boyle Chemical Co., Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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DKMbiochem.Co. Ltd

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View Lastest Price from BMS 303141 manufacturers

Career Henan Chemical Co

Product: BMS 303141 943962-47-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

943962-47-8, BMS 303141Related Search:

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BMS 303141

BMS30314

3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)benzenesulfonamide

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide BMS 303141

BMS 303141, >=98%

3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide

CS-887

BMS303141; BMS 303141

Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-

BMS-303141 >=98% (HPLC)

3,5-Dichloro-2-hydroxy-N-(4-methoxy-[1,1'-biphenyl]-3-yl)benzenesulfonamide

BMS-303141, 10 mM in DMSO

CAS:943962-47-8

BMS303141 ，S0277

943962-47-8

Inhibitors