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XL-652

Product Name
XL-652
CAS No.
918348-67-1
Chemical Name
XL-652
Synonyms
BMS788;XL-652;BMS-788;BMS 788;BMS-779788;EXEL04286652;XL-652, >98%;EXEL-04286652;EXEL 04286652;BMS-779788, >98%
CBNumber
CB83146428
Molecular Formula
C28H29ClN2O3S
Formula Weight
509.06
MOL File
918348-67-1.mol
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XL-652 Property

Boiling point:
738.7±70.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:65.0(Max Conc. mg/mL);127.69(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);58.93(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);58.93(Max Conc. mM)
form 
A crystalline solid
pka
13.56±0.29(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27339
Product name
BMS 779788
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
27339
Product name
BMS 779788
Packaging
10mg
Price
$493
Updated
2024/03/01
Cayman Chemical
Product number
27339
Product name
BMS 779788
Packaging
5mg
Price
$262
Updated
2024/03/01
ChemScene
Product number
CS-6167
Product name
BMS-779788
Purity
98.23%
Packaging
25mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-6167
Product name
BMS-779788
Purity
98.23%
Packaging
50mg
Price
$450
Updated
2021/12/16
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XL-652 Chemical Properties,Usage,Production

Uses

BMS-779788 is a LXR partial agonist with IC50 values of 68 nM for LXRα and 14 nM for LXRβ.

in vivo

BMS-779788 induces LXR target genes in blood in vivo with an EC50=610 nM, a value similar to its in vitro blood gene induction potency. BMS-779788 is 29- and 12-fold less potent than the full agonist T0901317 in elevating plasma triglyceride and LDL cholesterol, respectively, with similar results for plasma cholesteryl ester transfer protein and apolipoprotein B[1]. In mice BMS-779788 displays peripheral induction of ABCA1 at 3 and 10 mpk doses with no significant elevation of plasma or hepatic triglycerides at these doses, showing an improved profile compared to a full pan-agonist[2].

References

[1] Kirchgessner TG, et al. Pharmacological characterization of a novel liver X receptor agonist with partial LXRα activity and a favorable window in nonhuman primates. J Pharmacol Exp Ther. 2015 Feb;352(2):305-14. DOI:10.1124/jpet.114.219923
[2] Kick E, et al. Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRβ. Bioorg Med Chem Lett. 2015 Jan 15;25(2):372-7. DOI:10.1016/j.bmcl.2014.11.029

XL-652 Preparation Products And Raw materials

Raw materials

Preparation Products

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XL-652 Suppliers

China 43 United States 6 Global 49
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Medi-tech Bioscientific Co., Ltd.
Tel
0519-83246372 13585352506
Fax
0519-83246372
Country
China
ProdList
1844
Advantage
58
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View Lastest Price from XL-652 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
XL 652 918348-67-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

918348-67-1, XL-652Related Search:

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  • XL-652
  • XL-652,BMS 779788
  • BMS-779788
  • BMS-779788(XL-652)
  • BMS 788
  • BMS-779788; BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652
  • BMS788
  • BMS-788
  • EXEL 04286652
  • EXEL04286652
  • EXEL-04286652
  • BMS-779788, >98%
  • XL-652, >98%
  • 1H-Imidazole-4-methanol, 2-[1-(2-chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-
  • Inhibitor,BMS779788,EXEL 04286652,Liver X receptor,inhibit,BMS 779788,LXR,BMS 788,BMS-779788,EXEL-04286652,BMS788
  • 2-{2-[2-(2-chlorophenyl)propan-2-yl]-1-{3'-methanesulfonyl-[1,1'-biphenyl]-4-yl}-1H-imidazol-4-yl}propan-2-ol
  • 2-[1-(2-Chlorophenyl)-1-methylethyl]-α,α-dimethyl-1-[3'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]-1H-imidazole-4-methanol
  • BMS-779788, 10 mM in DMSO
  • 2-(2-(2-(2-chlorophenyl)propan-2-yl)-1-(3'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl)-1h-imidazol-4-yl)propan-2-ol
  • 918348-67-1