ChemicalBook > CAS DataBase List > 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

Product Name
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
CAS No.
1675201-83-8
Chemical Name
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
Synonyms
BMS-1;T3655;CS-2413;avelumab/PD-L1;PD-1PD-L1 inhibitor;PD1-PDL1 inhibitor 1;PD-1/PD-L1 inhibitor 1(C1);BMS-1 (PD-1/PD-L1 inhibitor 1);PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1);PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)
CBNumber
CB23049190
Molecular Formula
C29H33NO5
Formula Weight
475.58
MOL File
1675201-83-8.mol
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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Property

Boiling point:
630.2±55.0 °C(Predicted)
Density 
1.182±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
form 
solid
pka
2.34±0.20(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19914
Product name
PD-1/PD-L1 Inhibitor 1
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
19914
Product name
PD-1/PD-L1 Inhibitor 1
Purity
≥98%
Packaging
5mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
19914
Product name
PD-1/PD-L1 Inhibitor 1
Purity
≥98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
19914
Product name
PD-1/PD-L1 Inhibitor 1
Purity
≥98%
Packaging
25mg
Price
$384
Updated
2024/03/01
ChemScene
Product number
CS-5545
Product name
BMS-1
Purity
99.61%
Packaging
100mg
Price
$1056
Updated
2021/12/16
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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties,Usage,Production

Description

PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1

Uses

BMS-1 is a PD-L1 inhibitor which is used in combination with LIF inhibitors for the treatment of cancers.

in vitro

pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].

IC 50

0.006-0.10 μm

References

1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Suppliers

China 89 India 1 United States 13 Global 103
Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 13028896684
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sales@rrkchem.com
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China
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Shanghai Boyle Chemical Co., Ltd.
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86-21-57758967
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sales@boylechem.com
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China
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Chembest Research Laboratories Limited
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sales@BioChemBest.com
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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Dalian Meilun Biotech Co., Ltd.
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MedChemexpress LLC
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021-58955995
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United States
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TargetMol Chemicals Inc.
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021-33632979 15002134094
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marketing@targetmol.com
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China
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AdooQ Bioscience CHINA
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025-58849295 18951903616;
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025-68650336
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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+86-21-52996696
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China
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4121
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D&C Chemicals
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+86-21-58447131
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+86-21-61642470
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1724405207@qq.com
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China
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View Lastest Price from 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- manufacturers

Career Henan Chemical Co
Product
2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- 1675201-83-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
KG/T
Release date
2019-12-18

1675201-83-8, 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-Related Search:

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  • T3655
  • (2S)-1-{2,6-Dimethoxy-4-[(2-methyl-3-biphenylyl)methoxy]benzyl}-2-piperidinecarboxylic acid
  • 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
  • PD1-PDL1 inhibitor 1
  • PD-1PD-L1 inhibitor
  • (2S)-1-[[2,6-Dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid
  • avelumab/PD-L1
  • PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1)
  • BMS-1
  • BMS-1 (PD-1/PD-L1 inhibitor 1)
  • CS-2413
  • PD1/PDL1 INHIBITOR 1;PD 1/PD L1 INHIBITOR 1
  • PD-1/PD-L1 inhibitor 1(C1)
  • PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)
  • 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
  • (S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid
  • 1675201-83-8