PD-L1 inhibitor 1

Product Name: PD-L1 inhibitor 1
CAS No.: 1675203-84-5
Chemical Name: PD-L1 inhibitor 1
Synonyms: BMS-202;CS-2416;PD1 inhibitor 2;PD 1 inhibitor 2;PD-1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;PD-1/PD-L1 inhibitor 2(BMS-202);BMS202 (PD-1/PD-L1 inhibitor 2)
CBNumber: CB13043328
Molecular Formula: C25H29N3O3
Formula Weight: 419.52
MOL File: 1675203-84-5.mol

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PD-L1 inhibitor 1 Property

Boiling point:: 611.4±55.0 °C(Predicted)
Density: 1.133±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form: solid
pka: 16.06±0.46(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19132
Product name: PD-1/PD-L1 Inhibitor 2
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 19132
Product name: PD-1/PD-L1 Inhibitor 2
Purity: ≥98%
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 19132
Product name: PD-1/PD-L1 Inhibitor 2
Purity: ≥98%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 19132
Product name: PD-1/PD-L1 Inhibitor 2
Purity: ≥98%
Packaging: 25mg
Price: $576
Updated: 2024/03/01

TRC

Product number: B695175
Product name: BMS-202
Packaging: 10mg
Price: $310
Updated: 2021/12/16

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PD-L1 inhibitor 1 Chemical Properties,Usage,Production

Description

The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC₅₀ value of 18 nM.

Uses

BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.

References

1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857

PD-L1 inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD-L1 inhibitor 1 Suppliers

China 77 India 1 United States 14 Global 92

Shanghai Boyle Chemical Co., Ltd.

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Shanghai Send Pharmaceutical Technology Co., Ltd.

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View Lastest Price from PD-L1 inhibitor 1 manufacturers

Career Henan Chemical Co

Product: PD-L1 inhibitor 1 1675203-84-5
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg,10kg,100kg
Release date: 2020-01-09

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PD-L1 inhibitor 1

PD1-PDL1 inhibitor 2

N-[2-[[[2-Methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]acetamide

BMS-202

Acetamide, N-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-

PD 1 inhibitor 2

PD1 inhibitor 2

PD-1 inhibitor 2

PD-L1 inhibitor 2

PD-L1 INHIBITOR 2;PD-1 INHIBITOR 2;PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS 202;BMS202

PD-1/PD-L1 inhibitor 2(BMS-202)

CS-2416

N-{2-[({2-methoxy-6-[(2-methyl-3-phenylphenyl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide

PD1 INHIBITOR 2;PD 1 INHIBITOR 2;BMS202;BMS 202

BMS202 (PD-1/PD-L1 inhibitor 2)

N-(2-(((2-Methoxy-6-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)pyridin-3-yl)methyl)amino)ethyl)acetamide

1675203-84-5