PD-L1 inhibitor 1
- Product Name
- PD-L1 inhibitor 1
- CAS No.
- 1675203-84-5
- Chemical Name
- PD-L1 inhibitor 1
- Synonyms
- BMS-202;CS-2416;PD1 inhibitor 2;PD 1 inhibitor 2;PD-1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;PD-1/PD-L1 inhibitor 2(BMS-202);BMS202 (PD-1/PD-L1 inhibitor 2)
- CBNumber
- CB13043328
- Molecular Formula
- C25H29N3O3
- Formula Weight
- 419.52
- MOL File
- 1675203-84-5.mol
PD-L1 inhibitor 1 Property
- Boiling point:
- 611.4±55.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
- form
- solid
- pka
- 16.06±0.46(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $576
- Updated
- 2024/03/01
- Product number
- B695175
- Product name
- BMS-202
- Packaging
- 10mg
- Price
- $310
- Updated
- 2021/12/16
PD-L1 inhibitor 1 Chemical Properties,Usage,Production
Description
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.
Uses
BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.
References
1) Zak?et al.?(2016),?Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1);?Oncotarget?7?30323 2) Guzik?et al.?(2017),?Small-molecule inhibitors of the programmed cell death -1/programmed cell death -ligand 1(PD-1/PD-L1) interaction via transiently induced protein states and dimerization of PD-L1;?J. Med. Chem.?60?5857
PD-L1 inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
PD-L1 inhibitor 1 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from PD-L1 inhibitor 1 manufacturers
- Product
- PD-L1 inhibitor 1 1675203-84-5
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg,10kg,100kg
- Release date
- 2020-01-09