PD-L1 inhibitor 1
- Product Name
- PD-L1 inhibitor 1
- CAS No.
- 1675203-84-5
- Chemical Name
- PD-L1 inhibitor 1
- Synonyms
- BMS-202;CS-2416;PD1 inhibitor 2;PD 1 inhibitor 2;PD-1 inhibitor 2;PD-L1 inhibitor 2;PD-L1 inhibitor 1;PD1-PDL1 inhibitor 2;BMS-202, 10 mM in DMSO;PD-1/PD-L1 inhibitor 2(BMS-202)
- CBNumber
- CB13043328
- Molecular Formula
- C25H29N3O3
- Formula Weight
- 419.52
- MOL File
- 1675203-84-5.mol
PD-L1 inhibitor 1 Property
- Boiling point:
- 611.4±55.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to at least 25 mg/ml)
- form
- solid
- pka
- 16.06±0.46(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $321
- Updated
- 2024/03/01
- Product number
- 19132
- Product name
- PD-1/PD-L1 Inhibitor 2
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $576
- Updated
- 2024/03/01
- Product number
- B695175
- Product name
- BMS-202
- Packaging
- 10mg
- Price
- $310
- Updated
- 2021/12/16
PD-L1 inhibitor 1 Chemical Properties,Usage,Production
Description
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM.
Uses
BMS-202 is a Novel inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface.
in vivo
BMS-202 (20 mg/kg; intraperitoneal injection; daily; for 9 days; NOG-dKO mice) treatment shows a clear antitumor effect compared with the controls, in humanized MHC- dKO NOG mice[2].
| Animal Model: | NOG-dKO mice (8-week-old) injected with SCC-3 cells[2] |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 9 days |
| Result: | Showed 41% growth inhibitory activity against humanized mouse-transplanted human lymphoma SCC-3 cells. |
References
[1] KRZYSZTOF M ZAK. Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).[J]. Oncotarget, 2016: 30323-30335. DOI:10.18632/oncotarget.8730
[2] KATARZYNA GUZIK. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1[J]. Journal of Medicinal Chemistry, 2017, 60 13: 5857-5867. DOI:10.1021/acs.jmedchem.7b00293
PD-L1 inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
PD-L1 inhibitor 1 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from PD-L1 inhibitor 1 manufacturers
- Product
- PD-L1 inhibitor 1 1675203-84-5
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg,10kg,100kg
- Release date
- 2020-01-09