BMS-986299

Product Name: BMS-986299
CAS No.: 2242952-69-6
Chemical Name: BMS-986299
Synonyms: BMS-986299;BMS986299, 10 mM in DMSO;N-((4-Amino-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-2-yl)methyl)-N-ethylacetamide;Acetamide, N-[[4-amino-7-(1H-pyrazol-3-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethyl-
CBNumber: CB48871220
Molecular Formula: C18H19N7O
Formula Weight: 349.39
MOL File: 2242952-69-6.mol

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BMS-986299 Property

Boiling point:: 757.5±60.0 °C(Predicted)
Density: 1.407±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Slightly soluble: 0.1-1 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
form: Solid
pka: 11.46±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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BMS-986299 Chemical Properties,Usage,Production

Uses

BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. (patent WO2018152396A1).

IC 50

NLRP3: 1.28 μM (EC₅₀)

References

[1] Gary Glick, et al. Substituted imidazo - quinolines as nlrp3 modulators. WO2018152396A1.
[2] Gao G, et al., Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro. Front Pharmacol. 2022 Jul 5;13:906548. DOI:10.3389/fphar.2022.906548
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.

BMS-986299 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-986299 Suppliers

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2242952-69-6, BMS-986299Related Search:

BMS-1166 HCl BMS-986195 BMS-P5 BMS 193885 BMS 303141 BMS-345541 IKK Inhibitor III, BMS-345541 BMS-1001

BMS-986299

Acetamide, N-[[4-amino-7-(1H-pyrazol-3-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethyl-

N-((4-Amino-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-2-yl)methyl)-N-ethylacetamide

BMS986299, 10 mM in DMSO

2242952-69-6