ChemicalBook > CAS DataBase List > BMS-986299
BMS-986299
- Product Name
- BMS-986299
- CAS No.
- 2242952-69-6
- Chemical Name
- BMS-986299
- Synonyms
- BMS-986299;BMS986299, 10 mM in DMSO;N-((4-Amino-7-(1H-pyrazol-5-yl)-3H-imidazo[4,5-c]quinolin-2-yl)methyl)-N-ethylacetamide;Acetamide, N-[[4-amino-7-(1H-pyrazol-3-yl)-3H-imidazo[4,5-c]quinolin-2-yl]methyl]-N-ethyl-
- CBNumber
- CB48871220
- Molecular Formula
- C18H19N7O
- Formula Weight
- 349.39
- MOL File
- 2242952-69-6.mol
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BMS-986299 Property
- Boiling point:
- 757.5±60.0 °C(Predicted)
- Density
- 1.407±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: Slightly soluble: 0.1-1 mg/ml
Ethanol: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml - form
- Solid
- pka
- 11.46±0.40(Predicted)
- color
- White to off-white
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BMS-986299 Chemical Properties,Usage,Production
Uses
BMS-986299 (compound 112) is a first-in-class NLRP3 inflammasome agonist with an EC50 of 1.28 μM. (patent WO2018152396A1).
IC 50
NLRP3: 1.28 μM (EC50)
References
[1] Gary Glick, et al. Substituted imidazo - quinolines as nlrp3 modulators. WO2018152396A1.
[2] Gao G, et al., Cyclovirobuxine D Ameliorates Experimental Diabetic Cardiomyopathy by Inhibiting Cardiomyocyte Pyroptosis via NLRP3 in vivo and in vitro. Front Pharmacol. 2022 Jul 5;13:906548. DOI:10.3389/fphar.2022.906548
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
BMS-986299 Preparation Products And Raw materials
Raw materials
Preparation Products
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