ChemicalBook > CAS DataBase List > BMS-P5

BMS-P5

Product Name
BMS-P5
CAS No.
1550371-22-6
Chemical Name
BMS-P5
Synonyms
BMS-P5;BMS-P5 ，S9644;BMS-P5 free base;BMS-P5 free base, 10 mM in DMSO;(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-methanone;Methanone, [(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-;((2S,5R)-5-Amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone;BMS-P-5 free base,BMS P5 free base,myeloma,Inhibitor,inhibit,Protein Arginine Deiminase,BMS-P5,Multiple,NET,BMSP5 free base,Peptidylarginine Deiminase
CBNumber
CB48058175
Molecular Formula
C27H32N6O2
Formula Weight
472.58
MOL File
1550371-22-6.mol
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BMS-P5 Property

Boiling point:
728.7±70.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml,DMSO: 5 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/ml
form 
A crystalline solid
pka
9.87±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0140858
Product name
BMS-P5freebase
Purity
99.94%
Packaging
5mg
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-0140858
Product name
BMS-P5freebase
Purity
99.94%
Packaging
10mg
Price
$850
Updated
2021/12/16
ChemScene
Product number
CS-0140858
Product name
BMS-P5freebase
Purity
99.94%
Packaging
25mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-0140858
Product name
BMS-P5freebase
Purity
99.94%
Packaging
50mg
Price
$3000
Updated
2021/12/16
DC Chemicals
Product number
020562
Product name
BMS-P5
Packaging
003
Price
$3600
Updated
2021/12/16
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BMS-P5 Chemical Properties,Usage,Production

Uses

BMS-P5 free base is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 free base shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 free base blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model[1].

in vivo

BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice[1].
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression[1].

Animal Model:Syngeneic mouse model of MM[1].
Dosage:50 mg/kg.
Administration:Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result:Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.

References

[1] Marina Li, et al. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19(7):1530-1538. DOI:10.1158/1535-7163.MCT-19-1020

BMS-P5 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-P5 Suppliers

China 43 United States 4 Global 47
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
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65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4827
Advantage
55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4975
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
7999
Advantage
62
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2989
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58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
Advantage
68
Shanghai Yu Ben Biotechnology Co., Ltd.
Tel
021-61350663 15502154572
Fax
-
Email
1639466865@qq.com
Country
China
ProdList
493
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58

1550371-22-6, BMS-P5Related Search:

BMS-1166 HCl BMS-986195 BMS-986299 BMS 193885 BMS 303141 BMS-345541 IKK Inhibitor III, BMS-345541 BMS-1001

  • BMS-P5
  • Methanone, [(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-
  • BMS-P5 free base
  • BMS-P-5 free base,BMS P5 free base,myeloma,Inhibitor,inhibit,Protein Arginine Deiminase,BMS-P5,Multiple,NET,BMSP5 free base,Peptidylarginine Deiminase
  • ((2S,5R)-5-Amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone
  • (2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-methanone
  • BMS-P5 free base, 10 mM in DMSO
  • BMS-P5 ，S9644
  • 1550371-22-6
  • 1150371-22-6