ChemicalBook > CAS DataBase List > BMS-P5

BMS-P5

Product Name: BMS-P5
CAS No.: 1550371-22-6
Chemical Name: BMS-P5
Synonyms: BMS-P5;BMS-P5 ，S9644;BMS-P5 free base;BMS-P5 free base, 10 mM in DMSO;(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-methanone;Methanone, [(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-;((2S,5R)-5-Amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone;BMS-P-5 free base,BMS P5 free base,myeloma,Inhibitor,inhibit,Protein Arginine Deiminase,BMS-P5,Multiple,NET,BMSP5 free base,Peptidylarginine Deiminase
CBNumber: CB48058175
Molecular Formula: C27H32N6O2
Formula Weight: 472.58
MOL File: 1550371-22-6.mol

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BMS-P5 Property

Boiling point:: 728.7±70.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml,DMSO: 5 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:8): 0.11 mg/ml
form: A crystalline solid
pka: 9.87±0.40(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0140858
Product name: BMS-P5freebase
Purity: 99.94%
Packaging: 5mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0140858
Product name: BMS-P5freebase
Purity: 99.94%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0140858
Product name: BMS-P5freebase
Purity: 99.94%
Packaging: 25mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0140858
Product name: BMS-P5freebase
Purity: 99.94%
Packaging: 50mg
Price: $3000
Updated: 2021/12/16

DC Chemicals

Product number: 020562
Product name: BMS-P5
Packaging: 003
Price: $3600
Updated: 2021/12/16

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BMS-P5 Chemical Properties,Usage,Production

Uses

BMS-P5 free base is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC50 of 98 nM. BMS-P5 free base shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 free base blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model[1].

in vivo

BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice^[1].
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression^[1].

Animal Model:	Syngeneic mouse model of MM^[1].
Dosage:	50 mg/kg.
Administration:	Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result:	Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.

References

[1] Marina Li, et al. A Novel Peptidylarginine Deiminase 4 (PAD4) Inhibitor BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Delays Progression of Multiple Myeloma. Mol Cancer Ther. 2020 Jul;19(7):1530-1538. DOI:10.1158/1535-7163.MCT-19-1020

BMS-P5 Preparation Products And Raw materials

Raw materials

Preparation Products

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1550371-22-6, BMS-P5Related Search:

BMS-1166 HCl BMS-986195 BMS-986299 BMS 193885 BMS 303141 BMS-345541 IKK Inhibitor III, BMS-345541 BMS-1001

BMS-P5

Methanone, [(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-

BMS-P5 free base

BMS-P-5 free base,BMS P5 free base,myeloma,Inhibitor,inhibit,Protein Arginine Deiminase,BMS-P5,Multiple,NET,BMSP5 free base,Peptidylarginine Deiminase

((2S,5R)-5-Amino-2-methylpiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone

(2S,5R)-5-amino-2-methyl-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-7-methoxy-1-methyl-1H-methanone

BMS-P5 free base, 10 mM in DMSO

BMS-P5 ，S9644

1550371-22-6

1150371-22-6