ChemicalBook > CAS DataBase List > BMS 303141

BMS 303141

Product Name
BMS 303141
CAS No.
943962-47-8
Chemical Name
BMS 303141
Synonyms
CS-887;BMS30314;BMS 303141;BMS 303141, >=98%;BMS303141; BMS 303141;BMS-303141 >=98% (HPLC);BMS-303141, 10 mM in DMSO;3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide;3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide;3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)benzenesulfonamide
CBNumber
CB32627606
Molecular Formula
C19H15Cl2NO4S
Formula Weight
424.3
MOL File
943962-47-8.mol
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BMS 303141 Property

Boiling point:
591.5±60.0 °C(Predicted)
Density 
1.462±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
4.94±0.48(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0784
Product name
BMS-303141
Purity
≥98% (HPLC)
Packaging
5mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0784
Product name
BMS-303141
Purity
≥98% (HPLC)
Packaging
25mg
Price
$482
Updated
2024/03/01
Cayman Chemical
Product number
16239
Product name
BMS 303141
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16239
Product name
BMS 303141
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
16239
Product name
BMS 303141
Purity
≥98%
Packaging
25mg
Price
$388
Updated
2024/03/01
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BMS 303141 Chemical Properties,Usage,Production

Description

BMS-303141 (943963-47-8) is a potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells.1,2?Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice.2?A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia.2?Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells.3?Reduces cell cycle progression in iBN cells.4

Uses

BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.

Definition

ChEBI: 3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide is a member of biphenyls.

Biochem/physiol Actions

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.

storage

Store at -20°C

References

1) Li?et al. (2007),?2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors; Bioorg. Med. Chem.,?17?3208 2) Ma?et al.?(2009),?A novel direct homogeneous assay for ATP citrate lyase; J. Lipid Res.,?50?2131 3) Shah?et al.?(2016),?Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism; Oncotarget,?7?43713 4) Rhee and Dekoter (2017),?Regulation of Lipid Metabolism and Cell Cycle Progression by PU.1 in Myeloid Progenitor Cells; Blood,?130?2433

BMS 303141 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 303141 Suppliers

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View Lastest Price from BMS 303141 manufacturers

Career Henan Chemical Co
Product
BMS 303141 943962-47-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

943962-47-8, BMS 303141Related Search:

BMS-852927 XL-652 BMS-986142 BMS813160 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Insulin-like Growth Factor-1 Receptor Inhibitor PD-L1 inhibitor 1 AC480 (BMS-599626) BMS-P5 BMS 193885 BMS-345541 IKK Inhibitor III, BMS-345541 BMS-1001 JNJ 1661010 METYRAPONE C2 DIHYDROCERAMIDE Palmitoylethanolamide BMS-986299

  • BMS 303141
  • BMS30314
  • 3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide
  • 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)benzenesulfonamide
  • 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide BMS 303141
  • BMS 303141, >=98%
  • 3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide
  • CS-887
  • BMS303141; BMS 303141
  • Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-
  • BMS-303141 >=98% (HPLC)
  • 3,5-Dichloro-2-hydroxy-N-(4-methoxy-[1,1'-biphenyl]-3-yl)benzenesulfonamide
  • BMS-303141, 10 mM in DMSO
  • 943962-47-8
  • Inhibitors