ChemicalBook > CAS DataBase List > BMS 303141

BMS 303141

Product Name
BMS 303141
CAS No.
943962-47-8
Chemical Name
BMS 303141
Synonyms
CS-887;BMS30314;BMS 303141;CAS:943962-47-8;BMS303141 ，S0277;BMS 303141, >=98%;BMS303141; BMS 303141;BMS-303141 >=98% (HPLC);BMS-303141, 10 mM in DMSO;3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide
CBNumber
CB32627606
Molecular Formula
C19H15Cl2NO4S
Formula Weight
424.3
MOL File
943962-47-8.mol
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BMS 303141 Property

Boiling point:
591.5±60.0 °C(Predicted)
Density 
1.462±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
4.94±0.48(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0784
Product name
BMS-303141
Purity
≥98% (HPLC)
Packaging
5mg
Price
$121.6
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0784
Product name
BMS-303141
Purity
≥98% (HPLC)
Packaging
25mg
Price
$494.95
Updated
2025/07/31
Cayman Chemical
Product number
16239
Product name
BMS 303141
Purity
≥98%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
16239
Product name
BMS 303141
Purity
≥98%
Packaging
10mg
Price
$176
Updated
2024/03/01
Cayman Chemical
Product number
16239
Product name
BMS 303141
Purity
≥98%
Packaging
25mg
Price
$388
Updated
2024/03/01
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BMS 303141 Chemical Properties,Usage,Production

Description

BMS-303141 (943963-47-8) is a potent and selective ATP citrate lyase (ACL) inhibitor, IC50=0.13 μM. Inhibits lipid biosynthesis, IC50=8 μM in HepG2 cells.1,2?Reduces weight gain, lowers plasma cholesterol, triglycerides and glucose in high-fat-fed mice.2?A novel tool compound for exploring the potential of ACL inhibition as a target for metabolic disorders such as obesity and dyslipidemia.2?Impairs proliferation or induces death in androgen-depleted castration resistant prostate cancer cells.3?Reduces cell cycle progression in iBN cells.4

Uses

BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.

Definition

ChEBI: 3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide is a member of biphenyls.

Biochem/physiol Actions

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.

storage

Store at -20°C

References

[1] JAMES J. LI . 2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors[J]. Bioorganic & Medicinal Chemistry Letters, 2007, 17 11: Pages 3208-3211. DOI:10.1016/j.bmcl.2007.03.017
[2] ZHENGPING MA  Dong C  Ching Hsuen Chu. A novel direct homogeneous assay for ATP citrate lyase.[J]. Journal of Lipid Research, 2009, 50 10: 2131-2135. DOI:10.1194/jlr.d900008-jlr200
[3] SUPRIYA SHAH. Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism.[J]. Oncotarget, 2016: 43713-43730. DOI:10.18632/oncotarget.9666
[4] JESS RHEE R D. Regulation of Lipid Metabolism and Cell Cycle Progression By PU.1 in Myeloid Progenitor Cells[J]. Blood, 2017, 130 1: 2433-2433. DOI:10.1182/blood.v130.suppl\_1.2433.2433

BMS 303141 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS 303141 Suppliers

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Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from BMS 303141 manufacturers

Career Henan Chemical Co
Product
BMS 303141 943962-47-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20kg
Release date
2019-12-23

943962-47-8, BMS 303141Related Search:

BMS-852927 XL-652 BMS-986142 BMS813160 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Insulin-like Growth Factor-1 Receptor Inhibitor PD-L1 inhibitor 1 AC480 (BMS-599626) BMS-P5 BMS 193885 BMS-345541 IKK Inhibitor III, BMS-345541 BMS-1001 JNJ 1661010 METYRAPONE C2 DIHYDROCERAMIDE Palmitoylethanolamide BMS-986299

  • BMS 303141
  • BMS30314
  • 3,5-dichloro-2-hydroxy-N-(4-Methoxybiphenyl-3-yl)benzenesulfonaMide
  • 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)benzenesulfonamide
  • 3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide BMS 303141
  • BMS 303141, >=98%
  • 3,5-dichloro-2-hydroxy-N-(2-methoxy-5-phenylphenyl)benzenesulfonamide
  • CS-887
  • BMS303141; BMS 303141
  • Benzenesulfonamide, 3,5-dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-
  • BMS-303141 >=98% (HPLC)
  • 3,5-Dichloro-2-hydroxy-N-(4-methoxy-[1,1'-biphenyl]-3-yl)benzenesulfonamide
  • BMS-303141, 10 mM in DMSO
  • CAS:943962-47-8
  • BMS303141 ，S0277
  • 943962-47-8
  • Inhibitors