ChemicalBook > CAS DataBase List > IKK Inhibitor III, BMS-345541

IKK Inhibitor III, BMS-345541

Product Name
IKK Inhibitor III, BMS-345541
CAS No.
445430-58-0
Chemical Name
IKK Inhibitor III, BMS-345541
Synonyms
CS-1910;BMS345541 (free base);BMS-345541 (free base);BMS 345541 (free base);IKK Inhibitor III, BMS-345541;BMS345541;BMS 345541;IKK INHIBITOR III;IKK Inhibitor III, BMS-345541 USP/EP/BP;BMS-345541 free base (BMS345541 (free base);N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine;N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine
CBNumber
CB12618570
Molecular Formula
C14H17N5
Formula Weight
255.32
MOL File
445430-58-0.mol
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IKK Inhibitor III, BMS-345541 Property

Boiling point:
449.5±45.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
insoluble in H2O; ≥70 mg/mL in DMSO; ≥2.49 mg/mL in EtOH with gentle warming and ultrasonic
form 
Powder
pka
9.02±0.10(Predicted)
color 
White to off-white
CAS DataBase Reference
445430-58-0
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
401480
Product name
IKK Inhibitor III, BMS-345541 - CAS 445430-58-0 - Calbiochem
Purity
IKK Inhibitor III, BMS-345541, CAS 445430-58-0, is a cell-permeable, potent, selective, and allosteric site-binding inhibitor of IKK-2 (IC?? = ~ 300 nM).
Packaging
1MG
Price
$294
Updated
2023/06/20
TRC
Product number
B596080
Product name
BMS-345541
Packaging
25mg
Price
$495
Updated
2021/12/16
ChemScene
Product number
CS-1238
Product name
BMS-345541
Purity
99.57%
Packaging
50mg
Price
$500
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611365
Product name
BMS-345541 free base
Packaging
100mg
Price
$615.4
Updated
2021/12/16
ApexBio Technology
Product number
B4655
Product name
BMS-345541(freebase)
Packaging
50mg
Price
$470
Updated
2021/12/16
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IKK Inhibitor III, BMS-345541 Chemical Properties,Usage,Production

Characteristics

Allosteric IKK inhibitors have anti-inflammatory activity.

Uses

BMS-345541 is a potent, selective, and allosteric site-binding inhibitor of IKK β (IKK-2) and shows 10 times greater selectivity over IKK α (IKK-1). BMS-345541 also inhibits cellular Iκβα phosphorylation and has some anti-inflammatory properties.

Definition

ChEBI: N'-(1,8-dimethyl-4-imidazo[1,2-a]quinoxalinyl)ethane-1,2-diamine is a quinoxaline derivative.

Biological Activity

BMS-345541 highly selectively inhibits the catalytic subunits of IKK-2 and IKK-1 with IC50s of 0.3 μM and 4 μM, respectively.

in vitro

BMS-34554 (5 μM) induces time-dependent dephosphorylation of IκBα and p65. Treatment of T-ALL cells with BMS-34554 resulted in nuclear translocation of FOXO3a, including control of the expression level of the p21CIP1 gene. In human umbilical vein endothelial cells, BMS-345541 inhibits TNFα-induced expression of ICAM-1 and VCAM-1 with IC50 of 5 μM.

in vivo

BMS-345541 (100 mg/kg) reduced the cumulative arthritis damage score from 4.4 to 0, along with low-grade degradation and inflammation of the tibiotarsal joint, synovial hyperplasia, bone resorption, and severity of cartilage erosion. There was no apparent damage to the joints of the animals, which was indistinguishable from the histological phenotype observed in those from age-matched, disease-free control animals. BMS-345541 dose-dependently inhibited IL-1β signaling, with animals in the 100 mg/kg dose group exhibiting levels consistent with disease-free control animals.

target

TargetValue
IKK2
(Cell-free assay)		 0.3 μM
IKK1
(Cell-free assay)		 4 μM

IKK Inhibitor III, BMS-345541 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IKK Inhibitor III, BMS-345541 manufacturers

Career Henan Chemical Co
Product
BMS-345541 445430-58-0
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

445430-58-0, IKK Inhibitor III, BMS-345541Related Search:

BMS-1166 HCl BMS-986195 BMS-986299 BMS-P5 BMS 193885 BMS 303141 BMS-345541 BMS-1001 BAY 11-7082 IKK 16 Quizartinib (AC220) TPCA-1 Dabrafenib Crizotinib

  • IKK Inhibitor III, BMS-345541
  • BMS 345541 (free base)
  • BMS345541 (free base)
  • BMS-345541 (free base)
  • N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine
  • 1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-
  • N-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine BMS345541
  • N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)ethane-1,2-diamine
  • BMS345541;BMS 345541;IKK INHIBITOR III
  • CS-1910
  • BMS-345541 free base (BMS345541 (free base)
  • IKK Inhibitor III, BMS-345541 USP/EP/BP
  • N1-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine
  • BMS-345541,Inhibitor,inhibit,IκB kinase,IKK,BMS 345541,I kappa B kinase
  • 445430-58-0
  • IκB/IKK
  • Inhibitors
  • A cell-permeable quinoxaline compound that displays anti-inflammatory properties.
  • IKK