SC-514

ChemicalBook > CAS DataBase List > SC-514

Product Name: SC-514
CAS No.: 354812-17-2
Chemical Name: SC-514
Synonyms: SC-514;CS-707;GK01140;GK-01140;GK 01140;SC-514, >=98%;SC-514;GK 01140;SC-514 USP/EP/BP;IKK-2 Inhibitor, SC-514;4-Amino-[2,3']bithiophenyl-5-carboxamide
CBNumber: CB7832024
Molecular Formula: C9H8N2OS2
Formula Weight: 224.3
MOL File: 354812-17-2.mol

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SC-514 Property

Melting point:: 209-211°C
Boiling point:: 399.2±42.0 °C(Predicted)
Density: 1.450±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 15.63±0.50(Predicted)
form: powder
color: white to light brown
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0557
Product name: SC-514
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $93.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 401479
Product name: IKK-2 Inhibitor, SC-514
Packaging: 1mg
Price: $144
Updated: 2024/03/01

Cayman Chemical

Product number: 10010267
Product name: SC-514
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10010267
Product name: SC-514
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0557
Product name: SC-514
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $289
Updated: 2024/03/01

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SC-514 Chemical Properties,Usage,Production

Description

SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1

Chemical Properties

Yellow Solid

Uses

A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 μM). Shown to specifically block NF-kB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF.

Definition

ChEBI: 3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide is a ring assembly and a member of thiophenes.

storage

Store at +4°C

References

1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861

SC-514 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC-514 Suppliers

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354812-17-2, SC-514Related Search:

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SC-514, >=98%

3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide

SC-514;GK 01140

IKK-2 Inhibitor, SC-514

4-Amino-[2',3'-bithiophene]-5-carboxamide

SC-514

5-(Thien-3-yl)-3-aminothiophene-2-carboxamide

GK 01140

GK01140

GK-01140

4-Amino-[2,3']bithiophenyl-5-carboxamide

[2,3'-Bithiophene]-5-carboxamide, 4-amino-

4-Amino-[2,3']bithiophenyl-5-carboxamide GK 01140

4-Amino-[2,3"]bithiophenyl-5-carboxylic acid amide

IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

GK 01140; SC 514; SC514; GK-01140; GK01140

CS-707

SC-514 USP/EP/BP

IKK,I kappa B kinase,GK-01140,SC-514,GK01140,IκB kinase,Inhibitor,SC514,SC 514,inhibit

4-Amino-[2,3'-bithiophene]-5-carboxamide

354812-17-2

NF-kB

IκB/IKK

Apis

All Inhibitors

Inhibitors