25-hydroxy Cholesterol-d6
- Product Name
- 25-hydroxy Cholesterol-d6
- CAS No.
- 88247-69-2
- Chemical Name
- 25-hydroxy Cholesterol-d6
- Synonyms
- 25-hydroxy Cholesterol-d6;cholest-5-ene-3,25-diol-d6;cholest-5-ene-3β,25-diol-d6;CHOLEST-5-ENE-3,25-DIOL-D6;25-HYDROXYCHOLESTEROL-D6;(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-7,7,7-trideuterio-6-hydroxy-6-(trideuteriomethyl)heptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
- CBNumber
- CB42589994
- Molecular Formula
- C27H40D6O2
- Formula Weight
- 408.689910668
- MOL File
- 88247-69-2.mol
25-hydroxy Cholesterol-d6 Property
- Melting point:
- >155°C (dec.)
- storage temp.
- -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H370Causes damage to organs
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 11099
- Product name
- 25-hydroxy Cholesterol-d6
- Purity
- ≥99% deuterated forms (d1-d6)
- Packaging
- 500μg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 11099
- Product name
- 25-hydroxy Cholesterol-d6
- Purity
- ≥99% deuterated forms (d1-d6)
- Packaging
- 1mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 11099
- Product name
- 25-hydroxy Cholesterol-d6
- Purity
- ≥99% deuterated forms (d1-d6)
- Packaging
- 5mg
- Price
- $486
- Updated
- 2024/03/01
- Product number
- 160140
- Product name
- 25-Hydroxy Cholesterol-d6
- Packaging
- 1mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- H918032
- Product name
- 25-HydroxyCholesterol-d6
- Packaging
- 10mg
- Price
- $1190
- Updated
- 2021/12/16
25-hydroxy Cholesterol-d6 Chemical Properties,Usage,Production
Uses
25-Hydroxy Cholesterol-d6, is the labeled analogue of 25-Hydroxy Cholesterol (H918030), which is an oxygenated derivative of Cholesterol (C432501); an oxysterol. An inhibitor of human immunodeficiency virus replication in vitro. It also induces apoptosis in human monocytic cell lines as well as inducing apoptosis in CEM cells associated with negative regulation of c-Myc.
General Description
25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol.
Biochem/physiol Actions
25-hydroxycholesterol inhibits cholesterol biosynthesis by downregulating the function of 3-hydroxy-3-methylglutaryl-CoA reductase. It is found to be implicated in atherosclerosis. 25-hydroxycholesterol levels are known to be increased in hypercholesterolemic condition.
25-hydroxy Cholesterol-d6 Preparation Products And Raw materials
Raw materials
Preparation Products
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