HTS 01037

Product Name: HTS 01037
CAS No.: 682741-29-3
Chemical Name: HTS 01037
Synonyms: HTS 01037;HTS 01037 (HTS01037;4-{[2-(methoxycarbonyl)-5-(2-thinyl)-3-thienyl]amino}-4-oxo-2-butenoic acid;[2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-, 5-methyl ester
CBNumber: CB42591315
Molecular Formula: C14H11NO5S2
Formula Weight: 337.37
MOL File: 682741-29-3.mol

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HTS 01037 Property

Boiling point:: 621.2±55.0 °C(Predicted)
Density: 1.493±0.06 g/cm3(Predicted)
storage temp.: RT
solubility: Soluble in DMSO (up to 50 mg/ml)
pka: 3.39±0.10(Predicted)
form: solid
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2374
Product name: HTS01037
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $63.84
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2374
Product name: HTS01037
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $271
Updated: 2025/07/31

Cayman Chemical

Product number: 10699
Product name: HTS 01037
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10699
Product name: HTS 01037
Purity: ≥98%
Packaging: 5mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 10699
Product name: HTS 01037
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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HTS 01037 Chemical Properties,Usage,Production

Description

Adipocyte fatty acid binding protein (A-FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism. Molecular disruption of A-FABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. HTS 01037 is a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (K_i = 0.67 μM) that presumably competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2. At a concentration of 10 μM, HTS 01037 antagonizes the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes. HTS 01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-stimulated inflammation in bone marrow-derived macrophages, both effects of which are similar to the phenotype of A-FABP/aP2 knockout mice.

Uses

HTS 01037 is an inhibitor of fatty acid binding protein and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2.

Definition

ChEBI: HTS 01037 is a ring assembly and a member of thiophenes.

References

[1] ANN V. HERTZEL. Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins[J]. Journal of Medicinal Chemistry, 2009, 52 19: 6024-6031. DOI:10.1021/jm900720m
[2] ERIC K. LONG . Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2013, 1831 7: Pages 1199-1207. DOI:10.1016/j.bbalip.2013.04.004
[3] HONGLIANG XU. Uncoupling lipid metabolism from inflammation through fatty acid binding protein-dependent expression of UCP2.[J]. Molecular and Cellular Biology, 2015, 35 6: 1055-1065. DOI:10.1128/mcb.01122-14
[4] K. STEEN D B Hongliang Xu. FABP4/aP2 Regulates Macrophage Redox Signaling and Inflammasome Activation via Control of UCP2[J]. Molecular and Cellular Biology, 2016, 37 1. DOI:10.1128/mcb.00282-16
[5] MARCEL BOSS. FABP4 inhibition suppresses PPARγ activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages[J]. Atherosclerosis, 2015, 240 2: Pages 424-430. DOI:10.1016/j.atherosclerosis.2015.03.042

HTS 01037 Preparation Products And Raw materials

Raw materials

Preparation Products

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HTS 01037 Suppliers

CHINA 43 United States 5 USA 1 Global 49

Shanghai EFE Biological Technology Co., Ltd.

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682741-29-3, HTS 01037Related Search:

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HTS 01037

HTS 01037 (HTS01037

4-{[2-(methoxycarbonyl)-5-(2-thinyl)-3-thienyl]amino}-4-oxo-2-butenoic acid

[2,2'-Bithiophene]-5-carboxylic acid, 4-[(3-carboxy-1-oxo-2-propen-1-yl)amino]-, 5-methyl ester

682741-29-3