ChemicalBook > CAS DataBase List > TTP 22

TTP 22

Product Name: TTP 22
CAS No.: 329907-28-0
Chemical Name: TTP 22
Synonyms: TTP 22;CS-886;TTP 22, >97%;TTP22; TTP-22;TTP 22, >=98%;TTP 22, 10 mM in DMSO;Casein Kinase,Inhibitor,TTP-22,TTP 22,inhibit,TTP22;3-(5-P-TOLYLTHIENO[2,3-D]PYRIMIDIN-4-YLTHIO)PROPANOIC ACID;3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid;Propanoic acid, 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]-
CBNumber: CB42596587
Molecular Formula: C16H14N2O2S2
Formula Weight: 330.42
MOL File: 329907-28-0.mol

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TTP 22 Property

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥16.5 mg/mL in DMSO; ≥7.85 mg/mL in EtOH with gentle warming and ultrasonic
form: solid
color: White to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17702
Product name: TTP 22
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17702
Product name: TTP 22
Purity: ≥95%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 17702
Product name: TTP 22
Purity: ≥95%
Packaging: 10mg
Price: $199
Updated: 2024/03/01

Cayman Chemical

Product number: 17702
Product name: TTP 22
Purity: ≥95%
Packaging: 50mg
Price: $836
Updated: 2024/03/01

Tocris

Product number: 4432
Product name: TTP22
Purity: ≥98%(HPLC)
Packaging: 10
Price: $203
Updated: 2021/12/16

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TTP 22 Chemical Properties,Usage,Production

Uses

TTP 22 is a CK2 inhibitor.

Biological Activity

ttp 22 is a high affinity, atp-competitive casein kinase 2 (ck2) inhibitor.casein kinase 2 (ck2) noticeably stands out against a background of the kinase family due to its constitutive catalytic activity with the ability to phosphorylate more than 300 physiological substrates. these features make ck2 appear greatly diverse points of cell signaling pathways and be involved in processes leading to the development of various disorders, especially cancer. thus, currently ck2 is regarded as druggable protein kinase target and can be used for the development of antitumor, anti-inflammatory and antiviral drugs.

in vitro

kinetic studies of ttp 22 showed that activity of (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids moiety was a result of its competition with atp molecule for the binding site. inhibition constant (ki) for ttp 22 was 40 nm. initial in vitro tests of ttp 22 and it analog on four serine/threonine (ask1, jnk3, aurora a and rock 1) and three tyrosine protein kinases (fgfr1, met and tie2) revealed their remarkable specificity towards ck2 [1].

IC 50

= 0.1 μm; ki= 40 nm

storage

Store at +4°C

References

[1] golub ag,bdzhola vg,briukhovetska nv,balanda ao,kukharenko op,kotey im,ostrynska ov,yarmoluk sm. synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase ck2. eur j med chem.2011 mar;46(3):870-6.

TTP 22 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TTP 22 manufacturers

Career Henan Chemical Co

Product: TTP 22 329907-28-0
Price: US $1.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-20

329907-28-0, TTP 22Related Search:

TTK21 TTNPB (Arotinoid Acid) Belizatinib

TTP 22

Propanoic acid, 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]-

3-[[5-(4-Methylphenyl)thieno[2,3-d]pyriMidin-4-yl]thio]propanoic acid

3-(5-P-TOLYLTHIENO[2,3-D]PYRIMIDIN-4-YLTHIO)PROPANOIC ACID

TTP 22 3-[[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]thio]propanoic acid

TTP 22, >=98%

3-[2-(3-HYDROXY-5-METHOXYPHENYL)ETHYL]-6-METHOXY-2-(3-METHYL-2-BU<WBR />TEN-1-YL)PHENOL

CS-886

TTP22; TTP-22

TTP 22, >97%

3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid

Casein Kinase,Inhibitor,TTP-22,TTP 22,inhibit,TTP22

TTP 22, 10 mM in DMSO

329907-28-0

Inhibitors