5-BroMo-1H-pyrazolo[4,3-b]pyridine
- Product Name
- 5-BroMo-1H-pyrazolo[4,3-b]pyridine
- CAS No.
- 1227628-78-5
- Chemical Name
- 5-BroMo-1H-pyrazolo[4,3-b]pyridine
- Synonyms
- 5-broMo-1H-pyrazolo[4;5-BroMo-1H-pyrazolo[4,3-b...;5-BroMo-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 5-bromo-;5-Bromo-1H-pyrazolo[4,3-b]pyridine
- CBNumber
- CB42597201
- Molecular Formula
- C6H4BrN3
- Formula Weight
- 198.02
- MOL File
- 1227628-78-5.mol
5-BroMo-1H-pyrazolo[4,3-b]pyridine Property
- Boiling point:
- 351.7±22.0 °C(Predicted)
- Density
- 1.894±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 9.68±0.40(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C6H4BrN3/c7-6-2-1-4-5(9-6)3-8-10-4/h1-3H,(H,8,10)
- InChIKey
- QWLXNBNVCRSNEX-UHFFFAOYSA-N
- SMILES
- C12C=NNC1=CC=C(Br)N=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BLN00049
- Product name
- 5-Bromo-1H-pyrazolo[4,3-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $1400
- Updated
- 2025/07/31
- Product number
- B997848
- Product name
- 5-Bromo-1H-pyrazolo[4,3-b]pyridine
- Packaging
- 10g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR933142
- Product name
- 5-Bromo-1H-pyrazolo[4,3-b]pyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- Y5248
- Product name
- 5-Bromo-1H-pyrazolo[4,3-b]pyridine
- Packaging
- 250mg
- Price
- $174
- Updated
- 2021/12/16
- Product number
- OR933142
- Product name
- 5-Bromo-1H-pyrazolo[4,3-b]pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
5-BroMo-1H-pyrazolo[4,3-b]pyridine Chemical Properties,Usage,Production
Synthesis
22282-96-8
110-46-3
1227628-78-5
To a stirred chloroform solution of 6-bromo-2-methyl-3-nitropyridine (5 g, 26.73 mmol) was added potassium acetate (3.14 g, 32.08 mmol) and acetic anhydride (10.9 g, 106 mmol) sequentially at 10 °C. The reaction mixture was stirred at 65 °C for 2 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was cooled to room temperature, followed by the addition of isoamyl nitrite (3.75 g, 32.06 mmol) dropwise over 15 minutes and 18-crown-6 (0.7 g, 2.67 mmol). The reaction mixture was continued to be stirred at 65 °C for 16 h. The progress of the reaction was likewise monitored by TLC. At the end of the reaction, it was cooled to room temperature and 120 mL of a mixture of methanol and water (1:1 volume ratio) was added to the reaction mixture, followed by the addition of potassium carbonate (34.48 g, 24.99 mmol) and potassium hydroxide (4.2 g, 74.97 mmol). The mixture was stirred at room temperature for 3 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate and the organic layer was separated and washed sequentially with water and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5-bromo-1H-pyrazolo[4,3-b]pyridine (5 g) as an off-white solid.
References
[1] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0595; 0596
5-BroMo-1H-pyrazolo[4,3-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BroMo-1H-pyrazolo[4,3-b]pyridine manufacturers
- Product
- 5-Bromo-1H-pyrazolo[4,3-b]pyridine 1227628-78-5
- Price
- US $1.10-9.90/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-18
- Product
- 5-BroMo-1H-pyrazolo[4,3-b]pyridine 1227628-78-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09