6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
- Product Name
- 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
- CAS No.
- 288628-05-7
- Chemical Name
- 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate
- Synonyms
- STX 64;ST-64667;BN 83495;STX64667;STX 64667;Irosustat;Irosustat(STX64);COUMATE. Irosustat.;DSLPMJSGSBLWRE-UHFFFAOYSA-N;STX64 - BN83495 | Irosustat | 667 Coumate
- CBNumber
- CB42597564
- Molecular Formula
- C14H15NO5S
- Formula Weight
- 309.34
- MOL File
- 288628-05-7.mol
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Property
- Melting point:
- 170.1-173.4 °C
- Boiling point:
- 544.1±60.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >20mg/mL
- form
- white powder
- pka
- 8.26±0.70(Predicted)
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- S1950
- Product name
- STX64
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $211
- Updated
- 2024/03/01
- Product number
- S1950
- Product name
- STX64
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $662
- Updated
- 2024/03/01
- Product number
- S687208
- Product name
- STX64
- Packaging
- 2.5mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- Axon2892
- Product name
- STX64-BN83495|Irosustat|667Coumate
- Purity
- 99%
- Packaging
- 5mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- API0005149
- Product name
- BN-83495
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $728
- Updated
- 2021/12/16
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Chemical Properties,Usage,Production
Uses
STX64 is a potent, irreversible inhibitor of steroid sulfatase.
Biochem/physiol Actions
STX64 is a potent, irreversible inhibitor of steroid sulfatase. Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties. STX64 (667 coumate) is a potent tricylic coumarin-based sulfamate that irreversibly inhibits STS activity (IC50 = 8 nM in a placental microsomal assay system). Estrone sulfamate (EMATE) is also a potent STS inhibitor, but has estrogenic activity.
storage
Store at -20°C
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Preparation Products And Raw materials
Raw materials
Preparation Products
6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c][1]benzopyran-3-yl sulfaMate Suppliers
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