1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-

Product Name: 1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-
CAS No.: 1111637-68-3
Chemical Name: 1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-
Synonyms: 5-Bromo-3-fluoro-7-azaindole;5-broMo-3-fluoro-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-;(R)-N-(3-(6-((4-(1,4-dimethyl-3-oxopiperazin-2-yl)phenyl)amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl)-2-methylphenyl)-4,5,6,7-tetrahydrobenzo[b]thiophene-2-carboxamide
CBNumber: CB42603896
Molecular Formula: C7H4BrFN2
Formula Weight: 215.02
MOL File: 1111637-68-3.mol

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1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Property

Density: 1.861±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.46±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 145034
Product name: 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
Purity: 95%
Packaging: 500mg
Price: $737
Updated: 2021/12/16

Matrix Scientific

Product number: 145034
Product name: 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
Purity: 95%
Packaging: 1g
Price: $1179
Updated: 2021/12/16

Alichem

Product number: 1111637683
Product name: 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
Packaging: 10g
Price: $1436.4
Updated: 2021/12/16

Alichem

Product number: 1111637683
Product name: 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
Packaging: 25g
Price: $2371.2
Updated: 2021/12/16

Alichem

Product number: 1111637683
Product name: 5-Bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridine
Packaging: 5g
Price: $902.88
Updated: 2021/12/16

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1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Chemical Properties,Usage,Production

Synthesis

183208-35-7

1111637-68-3

General procedure for the synthesis of 5-bromo-3-fluoro-1H-pyrrolo[2,3-b]pyridines from 5-bromo-7-azaindoles: first, 3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid (67) was prepared. Compound 65 (4 g, 20 mmol) was dissolved in a mixed solution of acetonitrile (500 mL) and acetic acid (100 mL), followed by the addition of Select-Fluor (10 g, 30 mmol). The reaction mixture was heated and reacted at 80°C overnight. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether/ethyl acetate, 5:1, v/v) to confirm complete consumption of compound 65. Upon completion of the reaction, the mixture was concentrated under reduced pressure and the residue was purified by silica gel fast column chromatography (eluent was petroleum ether/ethyl acetate, 10:1, v/v) to afford compound 66 (0.64 g, 13% yield) as an off-white solid.1H NMR (400 MHz, CDCl3): δ 9.434 (brs, 1H), 8.311-8.280 (m , 1H), 8.056-8.023 (m, 1H), 7.191 (s, 1H), 7.086-7.053 (m, 1H).

References

[1] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 51

1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro- Suppliers

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1111637-68-3, 1H-Pyrrolo[2,3-b]pyridine, 5-broMo-3-fluoro-Related Search:

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